ABSTRACT
Medullary thyroid carcinoma is a kind of neuroendocrine tumor that originates from calcitoninproducing parafollicular C-cells of the thyroid.Its incidence,diagnosis and treatment are unique.Ki67 is a nuclear antigen related to cell proliferation.It plays an important role in tumor occurrence and development,and it has important clinical significance in a variety of malignancies.Ki67 proliferation index has become classification index in neuroendocrine tumors of the gastrointestinal tract.In this paper,we review the study of medullary thyroid carcinoma and the expression of Ki67 in medullary thyroid carcinoma.
ABSTRACT
Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma measuring less than 10 mm in diameter. With the development of ultrasonic technology and the popularization of physical examination, the incidence of PTMC increased dramatically. Routine preoperative diagnostic methods include clinical examination, thyroid ultrasound and fine needle aspiration biopsy. But its treatment methods are still controversal. In this paper, we review literatures in recent years and discuss the clinical common problems of PTMC.
Subject(s)
Humans , Biopsy, Fine-Needle , Carcinoma , Diagnosis , General Surgery , Carcinoma, Papillary , Diagnosis , General Surgery , Incidence , Thyroid Cancer, Papillary , Thyroid Neoplasms , Diagnosis , General Surgery , ThyroidectomyABSTRACT
OBJECTIVE@#To investigate the expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma(MTC).@*METHOD@#The expression level of Ki67 and calcitonin was studied in 44 cases of medullary thyroid carcinoma tissue and 20 cases of adjacent nontumor tissue by SP immunohistochemistry.@*RESULT@#The positive expression of Ki67 and calcitonin in medullary thyroid carcinoma tissue were 86.36% (38/44) and 100.00% (44/44) respectively. There was a significant difference between carcinoma and normal thyroid tissue (P<0.01). The overexpression of Ki67 and calcitonin in medullary thyroid carcinoma had no relationship with gender and age of patients,but had relationship with size of tumor,clinical staging and lymph node metastasis (P<0.05). Meanwhile, Ki67 and calcitonon had no significant correlation with each other.@*CONCLUSION@#The overexpression of Ki67 and calcitonin may play important role in occurrence, development and metastasis of medullary thyroid carcinoma. It may be used as an important judgement for the biological behavior of medullary thyroid carcinoma.