ABSTRACT
Objective To explore the correlation between oxidative stress and the occurrence and progression of diabetic complications in the patients with diabetes. Methods The content of 24 h urinary 8-hydroxy-deoxyguanosine (8-OhdG) in diabetes mellitus (DM) group, diabetic nephropathy (DN) group, diabetic retinopathy (DR)group, diabetic foot(DF) group, diabetic neuropathy (DNP) group and control group were detected, and analyzed. Results The content of 24 h 8-OhdG in DM group, DN group, DR group, DF group, DNP group were significantly higher than that in the control group (P ＜ 0.01), and that in DN group, DR group, DF group, DNP group were significantly higher than that in DM group(P ＜ 0. 01), but the content of 24 h 8-OhdG among DN group, DR group, DF group and DNP group was not statistically signiticant(P ＞0. 05). Conclusion The correlation between the occurrence of diabetic and its complications oxidative stress and the Ievel of oxidative stress in the body was positive related.
ABSTRACT
Objective To investigate the stroke patients with heart failure and early laboratory diagnosis of NT-proBNP testing clinical significance. Methods 212 eases of cerebral infarction patients,63 eases of patients with cerebral hemorrhege,38 cases of healthy persons,were used to detect the plasma NT-proBNP level. Results Plasma NT-proBNP level was higher than the value of early warning of heart failure in patients with cerebral infarction in 32 cases,the positive rate was 15.1% ;cerebral hemorrhage in 8 eases,the positive rate was 12.70% ,compared with the centrol group was statistically significant. Conclusion Detection of NT-proBNP in stroke patients has important clini-cal significance on the prevention and treatment of complicated heart failure.