ABSTRACT
Objective@#To investigate the necessity of medication for patients with type Ⅲ prostatitis-like symptoms for less than 3 months.@*METHODS@#We enrolled in this study 171 outpatients with type Ⅲ prostatitis-like symptoms for less than 3 months in our hospital from November 2016 to October 2017, and randomly divided them into groups A (n = 57), B (n = 57) and C (n = 57). The patients of group A received tamsulosin, levofloxacin and health education, those of group B tamsulosin and health education, and those of group C health education only. Three months later, we evaluated the therapeutic effects according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores of the patients, 4-point reduction in the total score indicating effectiveness.@*RESULTS@#After 3 months of treatment, the total NIH-CPSI scores of the patients in groups A, B and C were decreased by (9.0 ± 2.9), (8.2 ± 3.4) and (8.6 ± 3.2) points respectively, all indicating effectiveness, the pain scores (4.2 ± 1.8), (4.0 ± 1.9) and (4.2 ± 1.6) points, the urinary symptom scores decreased by decreased by (2.4 ± 1.2), (2.4 ± 1.4) and (2.2 ± 1.2) points, and quality of life scores decreased by (2.4 ± 1.4), (1.9 ± 1.4) and (2.2 ± 1.3) points, none with statistically significant difference among the three groups (P > 0.05).@*CONCLUSIONS@#Health education is proved to have a therapeutic effect on type Ⅲ prostatitis-like symptoms similar to that of alpha receptor blockers.
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the effects of antihypertensive drugs on the erectile function and number of nNOS-containing nerve fibers in spontaneously hypertensive rats(SHRs).</p><p><b>METHODS</b>Eighteen male SHRs of six-weeks old were randomized into three groups: Vilsartan intervention group, Aldactone intervention group and control group. Vilsartan [30 mg/(kg.d)] and Aldactone [20 mg/(kg.d)] were administered by gavage to respective groups. After twelve weeks treatment, all SHRs were tested for erectile function and then killed for the detection of nNOS-containing nerve fibers by Streptaridin-peroxidase immunohistochemistry techniques (SP method).</p><p><b>RESULTS</b>The erection frequency in Vilsartan group was higher, compared with other two groups(P < 0.05), in which no significant difference was observed (P > 0.05). There was no significant difference in erection rates among these three groups. The number of nNOS-containing nerve fibers in two intervention groups was higher than the control group(P < 0.01), but no significant difference existed between these two groups(P > 0.05).</p><p><b>CONCLUSIONS</b>Vilsartan improves erectile function in SHRs while Aldactone doesn't. The difference can't be explained by the number of nNOS-containing nerve fibers, and it is probably related to the vascular reconstruction induced by angiotensin II receptor antagonists.</p>