ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.</p><p><b>METHODS</b>Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.</p><p><b>RESULTS</b>Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.</p><p><b>CONCLUSION</b>The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.</p>