ABSTRACT
Objective To explore the clinical significance of the blood lactic dehydrogenase(LDH), ?_2-microglobulin(?_2-MG),D-dimer measuring in the diagnosis and treatment of Non-Hodgkin lymphoma. Methods In 40 cases with NHL,LDH was measured by L-P continuous monitoring method,?_2-MG was measured by luminescent immunoassay,D-dimer was measured by immunoturbidimettic assay.Results The levels of the blood LDH,?_2-MG and D-dimer in patients with NHL were higher than those of in the controls(P 0.05).Con- clusion The levels of blood LDH,?_2-MG,D-dimer can be taken as an auxiliary clinical index to diagnose, classify the phase,evaluate the effectiveness of treatment and prognosis in the NHL patients,and have impor- tant clinical significance.
ABSTRACT
<p><b>AIM</b>To investigate intermittent hypoxia effects on splenocyte mitogen-induced proliferation.</p><p><b>METHODS</b>Rats were exposured to intermittent hypoxia in a hypobaric chamber 4 h/d for 1 d, 2 d, 5 d and 15 d.</p><p><b>RESULTS</b>5 km (10.8% O2) hypoxia for 1 d significantly inhibited ConA-induced splenocytes proliferation by--74.57% +/- 7.33% (P < 0.05). Hypoxia (5 km) for 2 d, 5 d and 15 d did not markedly affect splenocyte proliferation (97.03 +/- 7.18%, 104.5% +/- 8.38%, 99.55% +/- 3.8% respectively). Hypoxia 2 km (16.0% O2) for 1 d, 2 d, 5 d and 15 d had no influence on splenocytes proliferation (93.19% +/- 11.88%, 96.43% +/- 7.9%, 99.03% +/- 10.97%, 100.54% +/- 9.54% respectively). We also demonstrated that acute hypoxia exposure (5 km) 4 h significantly suppressed DNA contents of rat splenocytes by 76.22% +/- 7.06% (P < 0.05). The suppressed DNA synthesis were returned to control level after the hypoxia for 5 d and 15 d.</p><p><b>CONCLUSION</b>These results suggest that the acute hypoxia (5 km, 4 h) induces a transient suppression on splenic lymphocyte proliferation, and the intermittent hypoxia may induce an adaptation response of the splenocytes proliferation.</p>