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Chinese Journal of Experimental and Clinical Virology ; (6): 45-47, 2008.
Article in Chinese | WPRIM | ID: wpr-254145

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the infection of HEV in Quzhou area of Zhejiang Province.</p><p><b>METHODS</b>All sera from blood donors in the central blood bank of Quzhou from April 2006 to April 2007 were used. Anti-HEV IgG and anti-HEV IgM were measured by EIA. RT-PCR was also performed to the samples with positive anti-HEV IgM. Genotype and sequence homology were analyzed after sequencing.</p><p><b>RESULTS</b>The positive ratio of anti-HEV IgG was 40.60%, in which the male infection ratio was higher than the female significantly (43.09% VS 36.09%; chi2=22.6; P < 0.01). The infection ratio was increased with age. The positive ratio of anti-HEV IgM was 0.43%. The positive ratio of anti-HEV IgG and the titers of antibody were higher in the inferior clinical infectors with positive anti-HEV IgM than the negative ones (P < 0.05). Two samples were positive in HEV PCR among 21 samples with positive anti-HEV IgM. The toxemia ratio was 0.4% of all the donors. And the genotype of the two samples with toxemia were both HEV-IV.</p><p><b>CONCLUSION</b>The HEV infection was correlation with age and sex significantly and the infection occurred in the adults mainly in Quzhou area. HEV toxemia was not infrequency in the blood donors.</p>


Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Age Factors , Antibodies, Viral , Allergy and Immunology , Blood Donors , China , Epidemiology , Genotype , Hepatitis E , Epidemiology , Allergy and Immunology , Virology , Hepatitis E virus , Genetics , Allergy and Immunology , Immunoglobulin G , Allergy and Immunology , Immunoglobulin M , Allergy and Immunology , Sequence Analysis, DNA , Sequence Homology , Sex Factors , Toxemia , Epidemiology , Virology
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