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AIM: To observe the clinical efficacy of 8-0 polypropylene scleral-sutured fixed intraocular lens(IOL)suspension implantation with the double knots technique in aphakic eyes.METHODS: Retrospective case series study. The data of 30 aphakic cases(31 eyes, 22 males)that underwent IOL suspension in our hospital from January 2021 to November 2022 were collected. The suspension of IOL(AcrySof IQ or Tecnis ZCB00)was performed by 8-0 polypropylene scleral-sutured with the double knots technique. The visual acuity, intraocular pressure(IOP), IOL position and complications with at least 6 mo of follow-up were observed.RESULTS: The mean preoperative uncorrected visual acuity(UCVA, LogMAR)and best-corrected visual acuity(BCVA, LogMAR)were 2.53±0.78 and 0.35±0.26, respectively, which were 0.58±0.26 and 0.36±0.27 at 6 mo postoperatively, respectively. And the differences in UCVA were statistically significant(t=15.408, P<0.01), whereas the difference in BCVA was not(t=-1.677, P=0.104). There were no intraoperative complications, with IOL position all centered, but 3 eyes had IOL tilt, 2 eyes had intraocular hypertension, 5 eyes had corneal edema, and 1 eye had suture exposure postoperatively. There were no complications such as hyphema, vitreous hemorrhage, macular edema, corneal endothelial decompensation, hypotony, choroidal detachment, retinal detachment, fulminant superior choroidal hemorrhage, endophthalmitis, or others.CONCLUSION: The 8-0 polypropylene scleral-sutured fixed intraocular lens suspension implantation with the double knots technique can improve the postoperative visual acuity of aphakic patients, and fewer complications, which is an option for the treatment of aphakia, dislocation of the lens and ligament abnormalities.
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AIM:To establish a nomogram model to predict the effect of serum ferritin on diabetic retinopathy and evaluate the model.METHODS:A total of 21 variables, including ferritin, were screened by univariate and multivariate regression analysis to determine the risk factors of diabetic retinopathy. A nomogram prediction model was established for evaluation and calibration.RESULTS:Ferritin, duration of diabetes, hemoglobin, urine microalbumin, regularity of medication and body mass index were included in the nomogram model. The consistency index of the prediction model with serum ferritin was 0.813(95%CI: 0.748-0.879). The calibration curves of internal and external verification showed good performance, and the probability of the threshold suggested by the decision curve was in the range 10% to 90%. The model had a high net profit value.CONCLUSIONS:Serum ferritin is an important risk factor for diabetic retinopathy. A new nomogram model, which includes body mass index, duration of diabetes, ferritin, hemoglobin, urine microalbumin and regularity of medication, has a high predictive accuracy and could provide early prediction for clinicians.
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BACKGROUND: In recent years, more and more scaffold materials have been used to repair soft tissue defects, and the clinical repair effect of soft tissue defects is strongly associated with the source and performance of materials. OBJECTIVE: To summarize the research progress of preparation and application of different biological scaffolds in the field of oral and maxillofacial soft tissue defect repair. METHODS: PubMed and Medline were searched for articles published from 1966 to 2019 with the English key words of “materials, scaffold, biological scaffold, soft tissue, coloboma, tissue engineering, review”. Chinese journal full-text database and Chinese science citation database were retrieved for articles published from 2003 to 2019 with key words of “material, scaffold, biological scaffold, soft tissue, defect, tissue engineering, review”. RESULTS AND CONCLUSION: Natural bio-scaffold materials are directly derived from organisms with pretty biocompatibility. Natural bio-scaffold materials can release cytoactive factors, promote cell adhesion, proliferation and differentiation, and can be combined with synthetic polymer materials with controllable properties to form composite scaffolds, which is an ideal scaffold material for repairing soft tissue defects of oral and maxillofacial regions. Nanomaterials have higher biological activity than other scaffold materials and can promote the adhesion and proliferation of seed cells, providing ideal three-dimensional space for cell growth, but their applications are currently mainly reflected in bone tissue repair, and the applications in soft tissue repair are very few. At present, there are many researches on natural biological scaffold materials in oral and maxillofacial soft tissue repair, mainly including small intestinal submucosa, acellular dermal matrix and acellular vascular scaffolds. The combination of natural biological scaffold materials and synthetic polymer materials will be a major research trend in materials for repairing oral and maxillofacial soft tissue defects.
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Objective To observe the effect of Tongmai Capsules(TC) on high-sensitivity C-reactive protein(hs-CRP) in acute coronary syndrome(ACS) patients.Methods Fifty-four ACS patients were randomized into the treatment group(N=26) and the control group(N=28).The two groups were given routine treatment for coronary heart disease and the complications.Additionally,the control group was given the placebo,and the treatment group was given TC,the treatment lasting one month.The change of the symptom scores was observed before and after treatment,and the hs-CRP level at the admission day,on the 7th day of treatment and after treatment for one month was also detected.Results(1) The score of symptoms of ACS was improved to various degrees in both groups(P0.05) while was decreased in the treatment group(P