Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy / 药学实践杂志

The great potential of cell therapy based on chimeric antigen receptor (CAR) has been demonstrated in the treatment of malignant tumors through 25 years of research .A large number of experimental and clinical data have been repor-ted in recent years .This review compares and analyzes these data to discuss how to enhance the efficacy of CAR-T cell therapy in the treatment of unresectable malignant tumors and to summarize the safety issues and solution strategies of CAR-T cell technology in the treatment of malignant tumors .