ABSTRACT
Objective:Through meta-analysis, the association of three common adipokines (leptin, adiponectin, and chemerin) with bone nutrition of senile osteoporosis (SOP) in China was systematically evaluated.Methods:CNKI, CBM, VIP, Wanfang, PubMed, Web of Science, Embase, Cochrane Library, and other databases were searched for articles published from the establishment of the database to July 30, 2022. After literature screening, data extraction, and quality evaluation of the included studies were independently conducted by two researchers, a meta-analysis was performed using RevMan5.4 and Stata17.0 softwares.Results:A total of 13 studies in the Chinese population were included, including 897 patients with SOP and 673 elderly with normal bone mineral density . The results of the meta-analysis showed that compared with the control group, the serum leptin levels were significantly lower ( MD -2.64, 95% CI -4.04 to -1.23, P < 0.001), chemerin levels were significantly higher ( MD 25.23, 95% CI 14.57 to 35.90, P < 0.001), and adiponectin levels were not significantly different ( MD -0.55, 95% CI -2.26 to 1.17, P > 0.05) in SOP patients. After subgroup analysis according to the measurement method, leptin levels remained lower in SOP patients than in the control group. Conclusions:Compared with the control group, leptin levels were lower and chemerin levels were higher in SOP patients. Therefore, dysregulation of adipokines may play an important role in the occurrence and development of SOP, and regulation of adipokine levels and functions may play a role in the treatment of SOP and the improvement of bone nutrition as a nutritional intervention.
ABSTRACT
BACKGROUND: The coupling and coordination control of the multi-link rigid body of human body is the key to stable walking. It is reported that the use of cell phones greatly increases the chance of falling down stairs when walking; however, it lacks the analysis of the dynamic stability, motion coordination and joint mechanics of the lower limbs when walking down stairs with cell phone intervention. OBJECTIVE: To investigate the effects of cell phone on coupling control strategy of the multi-link rigid body in lower extremity during stair descent. METHODS: Twenty healthy university students were recruited and conducted the stair descent under no-interference (single task) and cell phone (phone task) randomly. Using the method of synchronous acquisition of 3D kinematics and dynamics, the kinetic and kinematic data were synchronously collected to acquire the parameters of stair descent under both conditions. RESULTS AND CONCLUSION: (1) The intervention of phone task significantly reduced the dynamic stability in anterior-posterior/media-lateral direction, the first knee extension moment peak, the first dorsiflexion moment peak, the second hip flexion moment peak in sagittal plane during stance phase, and significantly increased the mean and standard deviation of hip-knee/knee-ankle relative phase angles during swing phase. (2) It is concluded that when the gait of human body changes from time to time, the coupling control ability of multi-link rigid bodies decreased and the risk of falling increased. (3) The intervention of phone task reduces the supporting moment of lower limbs in the supporting phase, reduces the stability of adjacent joint coordination control in the swinging phase, reduces the dynamic stability in front, back and inside directions, and increases the risk of falling.