ABSTRACT
Lung cancer has the highest mortality rate in the world. The first- and second-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) greatly improve the survival time and quality of life of patients with non-small cell lung cancer (NSCLC) to some extent. However, after a period of progression-free survival, most patients develop drug resistance, in which T790M mutation is the mainly resistance mechanism. The third-generation EGFR-TKIs, represented by osimertinib, are found to have significant effect on this resistance. The effect is remarkable, but drug resistance is still inevitable. For example, C797S mutation, mesenchymal-epithelial transition (MET), RAS mutation, BRAF mutation, transformation of small cell lung cancer (SCLC), transformation of epithelial mesenchymal transition (EMT), etc. But, there is no standard and effective treatment after the third-generation EGFR-TKIs resistance. In this view, we summarize the research progress in the new generation EGFR-TKIs after third-generation, in order to provide some reference for the follow-up research and treatment. .
ABSTRACT
OBJECTIVE@#To investigate the expression of B-cell translocation gene 1 (BTG1) and to determine the relationship between BTG1 expression and clinicopathological features, biological behaviors in laryngeal squamous cell carcinoma.@*METHOD@#Immunohistochemistry and Western blot were used to analyze BTG1 protein expression in 70 cases of laryngeal cancer and 35 cases of adjacent corresponding laryngeal mucosal tissues to illuminate the relationship between BTG1 expression and clinical factors.@*RESULT@#The positive rate of BTG1 protein expression was 31.43% in laryngeal carcinoma tissues, significantly lower than 91.43% in the adjacent laryngeal tissues (P 0.05) of patients with laryngeal cancer.@*CONCLUSION@#The expression of BTG1 protein was decreased in laryngeal squamous cell carcinoma, suggesting that BTG1 gene may be closely associated with the carcinogenesis and the degree of malignancy. Detection of BTG1 expression may be useful in diagnosis, treatment and prognosis of laryngeal carcinoma.
Subject(s)
Humans , Carcinoma, Squamous Cell , Metabolism , Pathology , Head and Neck Neoplasms , Metabolism , Pathology , Immunohistochemistry , Laryngeal Mucosa , Metabolism , Laryngeal Neoplasms , Metabolism , Pathology , Lymphatic Metastasis , Neoplasm Grading , Neoplasm Proteins , Metabolism , Neoplasm Staging , Prognosis , Squamous Cell Carcinoma of Head and NeckABSTRACT
Using the all closed covering low-temperature method, we successfully made the packaging and sampling of ethylene oxide standard.
Subject(s)
Ethylene Oxide , Reference Standards , Sterilization , MethodsABSTRACT
OBJECTIVE To investigate the diagnostic value of 131I-SPECT/CT fusion images in detecting the metastases of differentiated thyroid carcinoma(DTC)in the regions of the head,neck and superior mediastinum.METHODS 131I-SPECT/CT fusion images was preformed for 30 patients with DTC,and the results of image were compared with the pathology after surgery.RESULTS There were 110 cases positive findings in 115 metastatic lesions with 131I-SPECT/CT fusion images examination(95.65%).5 cases of the metastatic lesions showed negative in 131I-SPECT/CT(4.35%).There was no false positive case.CONCLUSION 131I-SPECT/CT fusion images can detect and locate the metastasis and exclude the false positive results accurately.It is a good method to detect the cervical and superior mediastinal metastatic lesion in differentiated thyroid carcinoma.
ABSTRACT
According to the Common Specification of Medical Electrical Equipment with GB 9706.1—2007 and the Environment Requirements and Testing Ways of Medical Electrical Equipment with GB/T 14710—1993,the solving methods in the electrical examination are put forward. Application of the practical method of operation,reasonable and effective protective measures to address the medical electrical equipment for general safety requirements and the environmental requirements test and the actual operation encountered some problems. The medical electrical equipment has been designed and tested in scientific and accurate electrical testing,electric shock protection,environmental testing,and the results of the operation specification.