ABSTRACT
Objective To observe the clinical efficacy of Yaoyi-Shenhuojiu combined with synthetic rehabilitation therapy on shoulder-hand syndrome after stroke (SHSAS). Methods 100 SHSAS patients were randomly divided into an observation group and a control group, with 50 patients in each group. Patients in the observation group were treated with Yaoyi-Shenhuojiu on the basis of comprehensive rehabilitation training of the control group. After treated for 2 consecutive weeks, the pain, motor function, activities of daily living in patients of both groups were compared and improvement of the constitution according to VAS, FMA, MBI was also compared. Results After treatment, the decrease of VAS score in the observation group (3.43 ± 1.76 vs. 5.21 ± 2.15, t=4.530) and the increase of FMA score (55.66 ± 4.33 vs. 40.45 ± 3.75, t=18.776) was significantly better than the control group (P<0.01); Physiological function in SF-36 health survey questionnaire (95.78 ± 7.68 vs. 87.88 ± 7.21, Z=5.042), physiological functions of (50.78 ± 21.44 vs. 36.89 ± 18.42, Z=7.241), body pain (83.22 ± 13.45 vs. 75.52 ± 13.23, Z=4.055), overall health (50.25 ± 18.45 vs. 39.01 ± 18.63, Z=8.043), vigor (79.28 ± 11.92 vs. 70.22 ± 10.69, Z=3.216), social function (85.78 ± 20.12 vs. 74.71 ± 19.22, Z=4.128), emotional function (36.66 ± 23.79 vs. 28.11 ± 18.21, Z=6.052) and mental health (81.17 ± 9.72 vs. 74.61 ± 11.25, Z=5.367) eight dimensions of higher score in the observation group were also significantly better than the control group (P<0.05). The total effective rate (94.0% vs. 76.0%) in the observation group was significantly better than the control group (χ2=5.020, P=5.020). Conclusion Yaoyi-Shenhuojiu combined with comprehensive rehabilitation therapy can effectively improve limb movement function in patients with SHSAS, besides its improving the life self-care ability and life quality.
ABSTRACT
This study was aimed to observe renoprotective effect and possible mechanism on Y i-Shui Sheng-Xin Yin in spontaneously hypertensive rats. Sixty 12-week male SHR rats were randomly divided into six groups , which were the Y i-Shui She ng-X in Y in low-dose group , middle-dose group , high-dose group , Benazepril group , model group and blank control group , and ten rats for each group . The SHR rats were sacrificed after eight weeks . The urine microalbumin , blood urea nitrogen and cystatin were tested in each rat . The HE and Masson staining method were used to observe changes of renal pathology . Changes of expression of transforming growth factor-β1 ( TGF-β1 ) , connective tissue growth factor ( CTGF ) , FN were detected by immunohistochemistry . The results showed that compared with the blank control group , blood pressure in model group was associated with a significant rise after 8 weeks. Compared with the model group, blood pressure in the Yi-Shui Sheng-Xin Yin middle-dose group, high-dose group and Benazepril group significantly decreased. Compared with the blank control group , urine microalbumin , blood urea nitrogen and cystatin in model group were associated with a significant rise . Compared with the model group , urine microalbumin , blood urea nitrogen and cystatin in the Y i-Shui She ng-X in Y in middle-dose group , high-dose group and Benazepril group significantly decreased . Pathological examinations showed that pathological changes in model group were faster than all drug-groups , appeared pathological changes of glomerular hypertrophy , glomerular basement membrane thickening of heterogeneity and extensive vacuoles degeneration . Immunohistochemical staining showed that compared with the blank control group , expressions of TGF-β1 , CTGF and FN of rat kidney tissue in model group were obviously up-regulated ( P < 0 . 05 ) . Compared with the model group , expressions of TGF-β1 , CTGF and FN in the Y i-Shui She ng-X in Y in , middle-dose group , high-dose group and Benazepril group were down-regulated ( P < 0 . 05 ) . It was concluded that Y i-Shui She ng-X in Y in can reduce SHR rats' early renal glomerulosclerosis and renal interstitial fibrosis , which play roles of delaying the progress of hypertension and protecting kidney . Its mechanism of action may be related to TGF-β1 , CTGF , FN signal pathways .
ABSTRACT
This paper reviewed the researches of TCM syndromes of rheumatoid arthritis in the past four years.The author believed that more and deeper epidemiological surveys are needed for studying rheumatoid arthritis and hence to improve its clinical effects.