ABSTRACT
【Objective】 To investigate the changes in left wrist pulse wave transit time （PTT） in patients with hypertension， as well as the effects of serological indicators and unhealthy lifestyle. 【Methods】 We recruited 321 hypertensive patients admitted to Chinese PLA General Hospital Hainan Branch from June 2020 to April 2021 and divided them into two groups according to the simple randomization method. Totally 135 patients in the control group drank 20 mL of water after getting up in the morning and 186 patients in the observation group took the nifedipine controlled release tablets on the basis of the control group. A smart watch was used to collect the PTT at 0.5 h， 4.5 h， and 8.5 h after taking the medicine （drinking water） for the two groups. Repeated measurement analysis of variance was used to observe the influences of the time， interaction effect， and medicine on PTT. The data of gender， age， height， weight， left arm circumference， left arm length， resting heart rate， smoking， and alcohol drinking were collected. Fasting blood of 4 mL was collected to detect indicators such as fasting blood glucose （FBG）， total cholesterol （TC）， triglyceride （TG）， and uric acid （UA） to analyze possible factors affecting PTT. 【Results】 The time effect was statistically significant （F=12.065， P<0.001）， while the interaction effect was not （F=0.089， P=0.915）. There was no statistically significant difference between the two groups （F=2.074， P=0.155）. FBG， TC， TG， resting heart rate， and limited alcohol drinking differed significantly （P<0.05）. 【Conclusion】 PTT gradually shortens with time， and it has no significant relationship with antihypertensive drugs， but may be related to FBG， TC， TG， resting heart rate， alcohol drinking and other indicators.