Clinical Observation of Calcitriol Soft Capsules Combined with Telmisartan Tablets in the Treatment of Early Diabetic Nephropathy / 中国药房

OBJECTIVE:To observe the clinical efficacy and safety of Calcitriol soft capsules combined with Telmisartan tab-lets in the treatment of early diabetic nephropathy(DN),and the effect on the levels of inflammatory factors. METHODS:Totally 110 patients with early DN were randomly divided into observation group and control group. The control group was orally given Telmisartan tablets with the initial dose of 40 mg,qd,and the maximum dose was 80 mg,qd;the observation group was orally giv-en Calcitriol soft capsules 0.25μg based on the treatment of control group,qd. The course was 1 month. The clinical data was com-pared,including the clinical efficacy and 24 h urinary protein,serum creatinine(Scr),urinary albumin excretion rate(UAER),se-rum C reactive protein (CRP),tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) before and after treatment. The adverse reactions were observed. RESULTS:After treatment,the total effective rate in observation group was significantly higher than con-trol group,with significant difference (P<0.05);the 24 h urinary protein,Scr,UAER,and levels of CRP,TNF-α and IL-6 in observation group were significantly lower than control group and before treatment,with significant differences(P<0.01 or P<0.05). There were no obvious adverse reactions in 2 groups. CONCLUSIONS:Calcitriol soft capsules combined with Telmisartan tablets has better efficacy than only Telmisartan tablets in the treatment of DN,and can more effectively improve the levels of CR, TNF-αand IL-6,which is helpful to delay progression of patients.

Parasitic Germplasm Resource and Control of Parasitosis for Domestic Animal and Poultry in Sichuan and South-western China / 中国寄生虫学与寄生虫病杂志

The object of using parasitic germplasm resource is to raise the technical level to control parsitosis for domestic animal and poultry.A total of 1 036 parasitic species collected from 16 kinds of domestic animals and poultries were reported in South-western China,where is one of the most serious areas for parasitosis transmission in China.This paper described the research and use of the new techniques on diagnosis,surveillance and control of parasitosis in domestic animal and poultry in Sichuan and South-western China,especially on applying resources of parasitic species in the pilot areas,so that the capacity of control and prevent of parasitosis in sheep,pig and dairy cattle farms were reasonably improved.