ABSTRACT
Objective:To systematically evaluate the effect of serum albumin content on the prognosis of patients with severe traumatic brain injury (TBI).Methods:PubMed, Embase, Cohrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), China Journals Full-text Database (CJFD), VIP database and Wanfang Database were used for retrieval from inception to November 10, 2020. Through retrieving Chinese and English literatures, relevant studies on serum albumin content in different types of TBI patients and in severe TBI patients with different prognostic results were included. The difference of serum albumin content in patinets with severe TBI with healthy people and patients with mild illness TBI, and the difference in serum albumin content between patients with good and poor prognosis of severe TBI were observed. At the same time, the differences in serum albumin content between subgroups were evaluated by subgroup analysis of the authors' country, literature quality and severity of the control group according to characteristics that might cause heterogeneity.Results:A total of 9 articles were included in this study, including 1, 438 study subjects. The serum albumin content in patients with severe TBI was significantly lower than that in healthy individuals and patients with mild TBI ( WMD=-6.42, 95% CI -9.95--2.80, Z=3.82, P<0.01). Subgroup analysis showed that serum albumin content in patients with severe TBI was significantly lower than that in healthy people ( WMD=-8.77, 95% CI-10.28--7.25, Z=11.37, P<0.01). Serum albumin content in patients with severe TBI was significantly lower than that in patients with mild TBI ( WMD=-4.07, 95% CI -9.53 -1.39, Z=1.46, P<0.05), suggesting that mild TBI patients are the main source of heterogeneity. The serum albumin content in patients with poor prognosis of severe TBI was significantly lower than that in patients with good prognosis of severe TBI ( WMD=-4.48, 95% CI-7.39--1.58, Z=3.02, P<0.01). Conclusion:Serum albumin content in patients with severe TBI is significantly lower than that in healthy individuals as well as in patients with mild TBI, and low albumin content indicates a poor prognosis in patients with severe TBI.