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Objective To explore the clinical effect of Shufeng Tongqiao and Yifei Jianpi prescription in the treatment of allergic rhinitis.Methods From September 2015 to October 2017,60 patients with allergic rhinitis in the Traditional Chinese Medicine Hospital of Tongxiang were selected according to include and exclude standards.The patients were randomly divided into two groups according to the digital table,with 30 cases in each group.The control group was treated with conventional western medicine:loratadine tablets combined with budesonide nasal spray.The treatment group was given traditional Chinese medicine on the basis of the control group.Before and after treatment,the nasal congestion,runny nose,nasal itching,sneezing four indicators were recorded in the two groups.And nasal discharge,tears flowed pharyngeal from eye pain,oral cavity on the forehead,nose,or pain,headache,five secondary indicators,as well as in the case of a change rhinitis,quality of life questionnaire were collected.The data were statistically analyzed.Results Before treatment,there were no statistically significant differences in the main symptoms,secondary symptoms,serum IgE and quality of life between the two groups (all P ＞ 0.05).After 3 months of treatment,all the indicators in the two groups were significantly improved compared with those before treatment,and the differences were statistically significant (all P ＜ 0.05).In addition,the improvement of main symptoms and serum IgE in the treatment group were better than those in the control group,and the differences were statistically significant (z/t =-2.708,-2.033,-3.757,-2.208,-2.432;P =0.007,0.042,0.000,0.027,0.018),but there were no statistically significant differences between the two groups in terms of subtypes and quality of life improvement (P =0.488,0.448,0.519,0.228,0.278,0.338).After 1 year of follow-up,the mean scores of each group were analyzed and compared.The indicators in the treatment group showed a different degree of recovery after 3 months of treatment.However,compared with before treatment,the indicators were still significantly improved.The scores of nasal obstruction,runny nose,nasal itching,sneezing,quality of life,and serum IgE in the treatment group were (1.13 ± 0.81) points,(1.00 ± 0.94) points,(0.93 ± 0.74) points,(1.00 ± 0.74) points,(6.13 ± 2.30) points,(92.23 ± 12.55)points,compared with those before treatment,the differences were statistically significant (t/z =-5.575,-5.222,-6.281,-5.918,5.633,9.199,all P ＜ 0.01).Compared with the control group,all indicators were significantly better,the differences were statistically significant (z/t =-2.388,-2.390,-2.738,-2.350,4.800,4.022,4.444,4.356,5.934,-2.023,-4.381;P =0.017,0.017,0.006,0.019,0.028,0.045,0.035,0.037,0.015,0.048,0.000).After 3 months of clinical treatment and 1 year follow-up analysis,the total effective rate of the treatment group was 93.3％,that of the control group was 86.7％,the difference between the two groups was statistically significant (Z =-2.221,P =0.026).Conclusion The clinical efficacy of Shufeng Tongqiao and Yifei Jianpi prescription combined with western medicine in the treatment of allergic rhinitis is more significant than conventional western medicine alone,and the long-term efficacy is significant,which can effectively reduce the symptoms of patients,improve the quality of life of patients,and significantly reduce the level of serum IgE.
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Objective@#To explore the clinical effect of Shufeng Tongqiao and Yifei Jianpi prescription in the treatment of allergic rhinitis.@*Methods@#From September 2015 to October 2017, 60 patients with allergic rhinitis in the Traditional Chinese Medicine Hospital of Tongxiang were selected according to include and exclude standards.The patients were randomly divided into two groups according to the digital table, with 30 cases in each group.The control group was treated with conventional western medicine: loratadine tablets combined with budesonide nasal spray.The treatment group was given traditional Chinese medicine on the basis of the control group.Before and after treatment, the nasal congestion, runny nose, nasal itching, sneezing four indicators were recorded in the two groups.And nasal discharge, tears flowed pharyngeal from eye pain, oral cavity on the forehead, nose, or pain, headache, five secondary indicators, as well as in the case of a change rhinitis, quality of life questionnaire were collected.The data were statistically analyzed.@*Results@#Before treatment, there were no statistically significant differences in the main symptoms, secondary symptoms, serum IgE and quality of life between the two groups (all P>0.05). After 3 months of treatment, all the indicators in the two groups were significantly improved compared with those before treatment, and the differences were statistically significant (all P<0.05). In addition, the improvement of main symptoms and serum IgE in the treatment group were better than those in the control group, and the differences were statistically significant (z/t=-2.708, -2.033, -3.757, -2.208, -2.432; P=0.007, 0.042, 0.000, 0.027, 0.018), but there were no statistically significant differences between the two groups in terms of subtypes and quality of life improvement (P=0.488, 0.448, 0.519, 0.228, 0.278, 0.338). After 1 year of follow-up, the mean scores of each group were analyzed and compared.The indicators in the treatment group showed a different degree of recovery after 3 months of treatment.However, compared with before treatment, the indicators were still significantly improved.The scores of nasal obstruction, runny nose, nasal itching, sneezing, quality of life, and serum IgE in the treatment group were (1.13±0.81)points, (1.00±0.94)points, (0.93±0.74)points, (1.00±0.74)points, (6.13±2.30)points, (92.23±12.55)points, compared with those before treatment, the differences were statistically significant (t/z=-5.575, -5.222, -6.281, -5.918, 5.633, 9.199, all P<0.01). Compared with the control group, all indicators were significantly better, the differences were statistically significant (z/t=-2.388, -2.390, -2.738, -2.350, 4.800, 4.022, 4.444, 4.356, 5.934, -2.023, -4.381; P=0.017, 0.017, 0.006, 0.019, 0.028, 0.045, 0.035, 0.037, 0.015, 0.048, 0.000). After 3 months of clinical treatment and 1 year follow-up analysis, the total effective rate of the treatment group was 93.3%, that of the control group was 86.7%, the difference between the two groups was statistically significant (Z=-2.221, P=0.026).@*Conclusion@#The clinical efficacy of Shufeng Tongqiao and Yifei Jianpi prescription combined with western medicine in the treatment of allergic rhinitis is more significant than conventional western medicine alone, and the long-term efficacy is significant, which can effectively reduce the symptoms of patients, improve the quality of life of patients, and significantly reduce the level of serum IgE.
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Objective To investigate the clinical effect of Shufeng Tongqiao,Yifei Jianpi therapy on persis-tent allergic rhinitis.Methods From January 2014 to February 2015,80 patients with allergic rhinitis in our hospital were chosen.Using random number table,they were randomly divided into control group and treatment group.The con-trol group was given western medicine,the treatment group was given self designed formula on the basis of the control group.The clinical symptoms,the efficacy and related indicators of the two groups before and after treatment were compared.Results After treatment for 3 months and 1 year,the IgE test results in the treatment and control groups were significantly lower than before treatment(t =13.93,14.45,12.11,7.46,all P <0.05),the IgE test results after 1 year of treatment in the treatment group was significantly lower than the control group (t =-4.59,P <0.05).IgE test results in the control group after one year of treatment was significantly higher than treatment for 3 months (t =-2.61,P <0.05 ).The total effective rate of the treatment group was 87.5%,which was significantly higher than 70.0% of the control group(P <0.05 ).Conclusion Shufeng Tongqiao,Yifei Jianpi method in the treatment of persistent allergic rhinitis has significant clinical effect,it can effectively alleviate rhinitis symptoms,stabilize serum IgE levels.
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Background and purpose:The signal transducers factor and activator in transcription 3(STAT3) is a recently studied gene from a variety of solid tumors such as breast, stomach, and ovarian cancer, in which the increase of abnormal expression and activity are accompanied.The aim of this study was to investigate the effects of eukaryotic vectors that express short hairpin RNA(shRNA) in signal transducers and activators of STAT3 on chemosensitivity of human ovarian cancer SKOV3 cells.Methods:Vectors containing shRNA targeting STAT3(pSTAT3-siRNA) were constructed and transfected into SKOV3 cells.These vectors were then divided into 3 groups:SKOV3, SKOV3NS, and SKOV3siRNA.The mRNA and protein expressions of STAT3 were determined by RT-PCR and Western blot, respectively.The growth inhibition and apoptosis rates of the different group cells under chemotherapeutic agents such as cisplatin(20 ?mol/L) were measured by MTT assay and flow cytometry(FCM).Results:MTT assay growth inhibition rates in the tumor cells of the SKOV3 group, SKOV3NS group and SKOV3siRNA group had inhibition rates of 0.46?0.13, 0.44?0.11 and 0.71?0.12.Compared with the SKOV3, SKOV3NS and SKOV3siRNA group, there was a marked increase of SKOV3siRNA group in inhibition rate of cells.The differences were also statistically significant(P0.05).The SKOV3 group, SKOV3NS group and SKOV3siRNA group's cell apoptosis rates were 18?4, 18?3 and 35?4, respectively.However, the SKOV3 group, SKOV3NS group, and SKOV3siRNA group cell apoptosis were significantly increased and the differences were statistically significant(P0.05).The results for the SKOV3 group, SKOV3NS group and SKOV3siRNA in cell STAT3 mRNA were 0.50?0.08, 0.48?0.07 and 0.31?0.09.With the SKOV3 group, SKOV3NS group, SKOV3siRNA group of cells in STAT3 mRNA, its expression in the lungs were significantly lower and the differences were statistically significant(P0.05).SKOV3 group, SKOV3NS group and SKOV3siRNA group of cells checked the results of STAT3 protein were 0.54?0.09, 0.56?0.08 and 0.32?0.09, respectively.The SKOV3 group, SKOV3NS group, and SKOV3siRNA group in STAT3 protein expression was significantly lower and the differences were statistically significant(P0.05).Conclusion:The STAT3 specific shRNA expression vector could effectively suppress the expression level of STAT3 gene in SKOV3 cells as well as enhance their sensitivity to cisplatin.