ABSTRACT
Objective To compare open reduction and internal fixation (ORIF) with closed reduction and internal fixation (CRIF) for the treatment of displaced fractures of the femoral neck in children,using a Meta-analysis.Methods Cochrane Library,PubMed Data,CNKI,Chinese Biomedical Database,Wanfang Data and Vip Data were searched for studies on treating displaced fractures of the femoral neck in children with ORIF and CRIF.In addition,hand search was conducted in relevant journals.Time limit for search was set from the beginning till August 2017.After eligible studies were included,a database was established of the demographic and clinical data of the patients included.Software Revman 5.0 was used for heterogeneity test of the quality of the studies included and the pooled relative risk (RR) and 95％ confidence interval (CI) were calculated.Results Ten studies were ultimately included involving 309 patients.Of them,163 were treated by ORIF and 146 by CRIF.The results showed that ORIF led to a significantly higher rate of anatomical reduction [RR =0.33,95％ CI (0.22,0.49),P ＜ 0.05] and a significantly higher good to excellent rate by Ratliff's evaluation [RR =0.73,95％ CI (0.62,0.85),P ＜0.05] than CRIF did;ORIF also led to a significantly lower rate of avascular necrosis[RR =1.93,95％ CI (1.13,3.31),P ＜ 0.05],a significantly lower rate of coxa vara [RR =2.38,95％ CI (1.07,5.27),P ＜0.05] and a significantly lower rate of nonunion [RR =2.72,95％ CI (1.05,7.04),P ＜ 0.05] than CRIF did.Conclusion In the treatment of displaced fractures of the femoral neck in children,ORIF can lead to better reduction,fewer complications and a higher good to excellent rate of functional recovery than CRIF.
ABSTRACT
Objective To determine standard of Scutellaria baicalensis extract with fingerprint characteristic. Methods HPLC technique had been used to determine the content of eight flavones in S. baicalensis extract by HPLC. Results S. baicalensis extract had relative stability of fingerprint characteristic. The characterization method of fingerprint and analysis mothod were precise and rapid. Conclusion The standard of S. baicalensis extract with fingerprint characteristic has been obtained. It can be used to control the quality of S. baicalensis extract and it can support the component of Chinese materia medica.
ABSTRACT
Objective To establish an HPLC-ESI-MS method for simultaneous analysis and determination of flavone in the seeds of Oroxylum indicum.Methods The separation was performed by Hypersil C_(18) column(250 mm?4.6 mm,5 ?m) with a mobile phase of formic acid aqueous solution(A) and acetonitrile(B) 0.5%.The flow rate was 1.0 mL/min and detection wavelength was at 195-400 nm.The samples were analyzed in positive mode.Results Six flavones in the seeds of O.indicum could be separated in one run.Baicalin,chrysin-7-glucuronide, oroxylin A,and baicalin-7-O-glucoside had been tentatively (identified) by ESI-MS and reference data.Conclusion Besides quantification of the components,this new method surpasses previously published ones in product quality control with accurate and rapid advantage,and provides the HPLC chromatographic fingerprints of biological active components in the seeds of O.indicum.