ABSTRACT
Objective To investigate the hypoglycemic effects of the ethanol extracts of Plantago asiatica in different diabetes animal models.Methods The different diabetes animal models (adrenaline -induced hyperglyce-mic models,glucose -induced hyperglycemic models,alloxan -induced hyperglycemic models)have been applied. Results Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(10.26 ±1.76)mmol/L] possessed obviously hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =2.558,P <0.01)and the middle dose[(11.74 ±2.35)mmol/L]possessed hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =1.524,P <0.05 );Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(11.38 ±1.76)mmol/L]possessed obviously hypoglycemic effects on glucose -induced hyperglycemic mice[(16.15 ±2.49)mmol/L](t =2.710,P <0.01 )and the middle dose [(13.01 ±3.23)mmol/L]possessed hypoglycemic effects on glucose -induced hyperglycemic mice(t =1.334,P <0.05);In addition,the ethanol extracts of Plantago asiatica could significantly inhibit the rise of blood glucose level and had certain hypoglycemic effect on halloxan -induced diabetic mice.Conclusion The ethanol extracts of Planta-go asiatica have a significant role in lowering blood glucose at a certain extent.
ABSTRACT
Objective To investigate the immunomodulatory effects of lyophilized royal jelly ( LRJ) on immunoglobulin IgG,IgA,IgM and complement C3 and C4 in patients with low immunity ,and to evaluate the clinical efficacy of LRJ.Methods A self-controlled clinical study of immunomodulatory efficacy of LRJ was performed in 32 patients with low immunity.Every patient took orally LRJ,two times a day.The hepatic function AST,ALT,and immunoglobulin IgG,IgA,IgM and complement C3,C4 were assayed after treatment for 28 days,and then the efficacy and safety of LRJ were evaluated.Results After took orally LRJ,the levels of IgG,IgA,and IgM [(10.31 ±2.03)g/L, (1.69 ±0.55)g/L,(1.51 ±0.55)g/L] were significantly higher than those before treatment [(8.52 ±1.94)g/L, (1.38 ±0.57)g/L,(1.36 ±0.55)g/L](t=5.21,2.25,1.56,all P0.05).Conclusion LRJ can increase the levels of immu-noglobulin IgG,IgA and IgM,thus to improve the symptoms of patients with low immunity .