ABSTRACT
Objective: To investigate the efficacy of percutaneous vertebroplasty (PVP) combined with intensity modulated radiation therapy (IMRT) for spinal vertebra metastases. Methods: Data of 106 patients with spinal metastases were retrospectively analyzed, including 38 patients underwent PVP combined with IMRT(PVP+IMRT group), 38 received PVP (PVP group) and 30 received IMRT (IMRT group). The pain visual analogue scale (VAS), tumors of spine instability score (SINS) and Karnofsky performance status score (KPS) were used to evaluate pain, spinal stability improvement and functional status. The adverse reaction and local progression were also observed. Kaplan-Meier was used to analyze the survival analysis, while Cox proportional hazard model was used to evaluate the correlations of survival and clinical factors. Results: There was no significant difference of local tumor progression among 3 groups 6 months after treatment (χ2=5.890, P=0.061). VAS were significant different among 3 groups 1 month, 3 months, 6 months and 12 months after treatment (all P0.05). Brain or visceral metastasis, KPS and the medical treatment were independent factors affecting prognosis. Conclusion: PVP combined with IMRT for spinal metastases is good at relieving pain, maintaining the stability of vertebral body and improving the functional status.
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Objective To evaluate the efficacy and safety of CT-guided 125I radioactive seed implantation combined with gemcitabine and Gio (gemcitabine and S-1, GS scheme) chemotherapy in treating advanced pancreatic carcinoma. Methods Sixty-eight patients with inoperable advanced pancreatic carcinoma were randomly divided into two groups. Patients in group A(n=38) were treated with CT-guided 125I radioactive seed implantation combined with GS chemotherapy scheme, while patients in group B (n=30) received GS chemotherapy scheme only. The short-term effect, the median progression-free survival time, the median survival time and adverse reactions of the two groups were determined , and the results were compared between the two groups. Results The objective response rate (ORR), disease control rate (DCR) and clinical benefit rate (CBR) of the group A were 57.9%, 73.7%and 84.2%respectively, while those of group B were 26.7%, 46.7% and 60.0% respectively. The differences between the two groups were statistically significant (P0.05). Conclusion For advanced pancreatic carcinoma, CT-guided 125I radioactive seed implantation combined with GS program is a safe and effective treatment.
ABSTRACT
Objective To investigate the value of CT-guided 125I particles implantation combined with gemcitabine plus S-1 (GS) regimen in the treatment of locally advanced pancreatic cancer.Methods 42 patients with unresectable local advanced pancreatic cancer were given with CT-guided 125I seed implantation.3-4 cycles of GS regimen was given based on the tolerance of patient s body within 3-7 d after implantation of particles.Review of blood,CA199,chest X-ray,CT scan + enhanced or MRI were performed at 2nd,4th,6th,12th month after surgery.Results 2nd,4th,6th month after surgery,tumor lesions were significantly reduced,ORRs were 59.5 ％ (25/42),66.7 ％ (28/42) and 73.8 ％ (31/42),respectively,DCRs were 83.3 ％ (35/42),78.6 ％ (33/42) and 76.2 ％ (32/42),respectively.No serious adverse reactions were observed,patient could tolerate these reactions.The 6th,12th,24th month survival rates were 100 ％ (42/42),47.6 ％ (20/42) and 11.9 ％ (5/42),respectively,mPFS was 8.27 months and mOS was 12.00 months.Conclusion CT-guided 125I particles implantation combined with GS regimen is convenient,safe,high efficacy in the treatment of locally advanced pancreatic cancer.