ABSTRACT
AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream. METHODS: 2% azone+1% volatile oil of twig from Camellia. oleifera was used as permeation enhancer to prepare Triptolide Compound Cream. Acute dermal toxicity, irritation a sensitization test on mouse were carried out. And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity, irritation or hypersensitive effects. 2% azone+1% volatile oil had more powerful enhancement effects, after 12 h, amont of drug delivery/unit area Q/( μg/cm~2) and absorption percentage Q% of tfiptolide and meloxican in the preparation reached a platea conventration. The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin, and there is a good dermal absorption.
ABSTRACT
AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream.METHODS: 2% azone+1% volatile oil of twig from Camellia.oleifera was used as permeation enhancer to prepare Triptolide Compound Cream.Acute dermal toxicity,irritation a sensitization test on mouse were carried out.And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity,irritation or hypersensitive effects.2% azone+1% volatile oil had more powerful enhancement effects.after 12 h,amont of drug delivery/unit area Q/(?g/cm2) and absorption percentage Q% of triptolide and meloxican in the preparation reached a platea conventration.The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin,and there is a good dermal absorption.