ABSTRACT
Objective To investigate expression of cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients with lung metastasis before treatment and their prognostic value. Methods The pretreatment serum expression levels of SCC-Ag and CYFRA21-1 of 72 cervical cancer patients with lung metastasis were measured. Survival rate analysis and Cox proportional hazard model were performed to evaluate the prognostic significance of two pretreatment variables. Results The media survival time (MST) of 72 patients was 14 months, and 38 (52.8 %) patients with pulmonary metastasis occurred in 1 year of treatment. The pretreatment serum SCC-Ag and CYFRA21-1 levels in the patients with tumor diameter over 4 cm or with squamous cell carcinoma were higher than those in the other patients (all P3.3 mg/L) was higher than that in the negative group (13 months vs 19 months, P1.5 mg/L) was also higher than that in the negative group (14 months vs 21 months, P<0.05). The result of Cox regression analysis showed that the tumor diameter (OR = 11.6, P = 0.01), pretreatment serum SCC-Ag (OR= 4.2, P= 0.01) and CYFRA21-1 (OR= 8.2, P= 0.05) levels were independent prognostic factors of overall survival. Conclusion Pretreatment CYFRA 21-1 and SCC-Ag levels may be considered as useful prognostic indicators for cervical cancer patients with lung metastasis.
ABSTRACT
Objective:To observe the destructive characteristics of the bovine liver induced by focused ultrasound clamp technique.Methods:A focused ultrasound surgical clamp(FUSC) consisted of two transducers fixed on a forceps-like handle.The directions of focused ultrasound beams were opposite,with the same central axes.The thickness of bovine liver in vitro ranged from 4 to 10cm.Ultrasound energy was continuously delivered to ablate the liver with a frequency of 1.6MHz,and spatial peak pulse average acoustic intensity(ISPPA) of 12 000W/cm2.The characteristics of complete coagulation necrosis and exposure time were measured after FUSC exposure,and pathological changes in treated bovine liver tissue were observed.Results:FUSC induced complete coagulation necrosis of predetermined bovine liver targets.The shape of coagulation necrosis was corresponded with focused ultrasound beam,with 2.72～3.20cm in length and 1.44～1.80cm in width.However,under the same exposure energy,exposure time for complete necrosis increased,as the thickness of the liver increased.Conclusion:FUSC can induce complete coagulation necrosis of predetermined bovine liver targets.This study would provide a novel surgical instrument for hepatectomy.