ABSTRACT
A Chinese medicine (CM) approach, designed based on the clinical experiences of the West Los Angeles Center for Traditional Chinese Medicine, is a practical path for assessing and treating breast cancer survivors. The approach consists of balancing the body with deciphering the cause of the patient's chief complaints by assessing and recognizing the six physiological dysfunctions that include gastrointestinal problems, sleeps problems, emotional imbalance, low body energy, menstrual change and pain. Multifaceted interventions are used for eliminating various CM pathologies based on identifying the basic CM patterns (syndromes) differentiation. Watching to assess the above two situations dynamically is used for outcome evaluation and predicting prognosis. Therefore this approach is called BMW. It can serve as a reference for CM clinical practice and integrative clinical care. It also can be used to simplify the clinical interpretation of CM and provide an easier way for CM doctors to communicate with Western medical doctors and patients. Additionally, it can be used as a guide for patients to assess their own symptoms for self-monitoring and self-care.
Subject(s)
Female , Humans , Middle Aged , Breast Neoplasms , Therapeutics , Medicine, Chinese Traditional , Methods , Practice Patterns, Physicians' , Survival AnalysisABSTRACT
<p><b>AIM</b>To investigate the protective effects of ginkgolide B and hypoxic preconditioning against acute hypoxia injury in mice.</p><p><b>METHODS</b>Ordinary pressure acute hypoxia model in mice was adopted to observe the ethology, the duration of the death and the degree of brain edema. Meanwhile the expression of RTP801 mRNA and erythropoietin (EPO) were measured by RT-PCR and Western blot, respectively.</p><p><b>RESULTS</b>Ginkgolide B and hypoxic preconditioning could both prolong the survival time of hypoxia under ordinary pressure,and significantly decreased the degree of brain edema. Besides ginkgolide B and hypoxic preconditioning could both up-regulate the expression of RTP801mRNA and EPO.</p><p><b>CONCLUSION</b>Ginkgolide B has the similar effect to hypoxic preconditioning against acute hypoxia. Both of these protective effects may be associated with the up-regulation of the expression of RTP801 mRNA and EPO.</p>
Subject(s)
Animals , Female , Male , Mice , Brain , Metabolism , Brain Edema , Erythropoietin , Metabolism , Ginkgolides , Pharmacology , Hypoxia , Ischemic Preconditioning , Methods , Lactones , Pharmacology , Mice, Inbred ICR , RNA, Messenger , Genetics , Metabolism , Reperfusion Injury , Repressor Proteins , Genetics , Metabolism , Up-RegulationABSTRACT
Erxian Tang is a Chinese herbal formula developed for the treatment of menopausal syndrome in women. In the past 50 years, EXT has shown positive efficacy in the treatment of many chronic diseases in TCM, involving syndrome types of Shen yin-yang deficiency, yin-deficiency caused yang-flourishing, and disharmony of Chong-Ren meridian. Experimental studies have revealed that EXT has multiple pharmacological actions on such multiple targets as hypothalamus-pituitary-target gland axis, immune function and free radical metabolism, etc.