ABSTRACT
A case report of pneumonia vaccination followed by death due to Guillain-Barré syndrome was fully presented and discussed. The association between the vaccination and Guillain-Barré syndrome could not be completely ruled out; however, the diagnosis of coincidental event was preferred, which may provide a reference for future similar case investigation.
ABSTRACT
Objective:To analyze the collected data of adverse events （AEFI） of pneumonia vaccine in Shanghai from 2010 to 2020，， so as to provide the appropriate immunization strategy and popularization of science for pneumonia vaccine . Methods:the data of suspected adverse events were collected from National AEFI Surveillance System during 2010 to 2020， and the vaccination information of pneumonia vaccine was obtained from Shanghai Vaccination Information System. Descriptive epidemiological method was used to analysis. Results:The total 18 446 AEFI cases were reported in Shanghai from 2010 to 2020， and the incidence rate was 425.0/100 000 doses. The general reactions were reported as 18 003 cases （97.6%）， with 393 cases of abnormal reactions （2.0%）， 57 cases of coincidences （0.3%）， 2 cases of psychogenic reactions （<0.1%） and no vaccine quality accident or vaccination accident was reported. There was no significant difference in the incidence rate between male and female； The incidence rate of AEFI decreased with the age of the old. The incidence rate of 23 valent pneumococcal polysaccharide vaccine （PPV23） AEFI was 476.5/100 000 doses， which was significantly lower than that of other kinds of pneumonia vaccine. The first dose was also significantly higher than that of non-first dose. Conclusion:The various types of pneumonia vaccines being used in Shanghai have high safety.
ABSTRACT
Objective:To analyze the safety of measles-containing vaccines （MCV） in Shanghai city. Methods:Adverse event following immunization cases related to measles attenuated live vaccine （MV）， measles and rubella combined attenuated live vaccine （MR） and measles， mumps and rubella combined attenuated live vaccine （MMR） vaccination in Shanghai during 2011—2018 were collected from the National AEFI Surveillance System for epidemiological analysis. Results:A total of 15 055 MVC-related AEFI cases were reported， for an incidence of 139.74 per 100 000 doses. Among all MVC-related AEFI cases， the male to female ratio was 1.17∶1， and 12 068 （111.70 per 100 000 doses） were common reactions， with 1 050 from MV（64.66 per 100 000）， 5 484 from MR（134.36 per 100 000）and 5 534 from MMR（108.60 per 100 000. Most of common reactions were fever （96.01 per 100 000）， but 2 939 （27.20 per 100 000） were rare reactions， with 408 from MV （25.12 per 100 000）， 1 983 from MR （48.59 per 100 000） and 548 from MMR （10.75 per 100 000）. Most of rare reactions were allergic rash （25.00 per 100 000）. Conclusion:MCV has a good safety profile but we should continue to strengthen MCV-related AEFI surveillance.
ABSTRACT
In order to ensure the safety of the vaccine cold chain to the greatest extent, the newly regulations still require daily manual recording of temperature data and operation conditions based on the configuration of the automatic temperature measurement and alarm system.Therefore, on the basis of Shanghai Vaccine Cold-chain Monitoring System, Shanghai has introduced an electronic signature technology to implement a new model of remotely checking the temperature by mobile-phone and keeping records of the electronic signature as certificates.This technology reduces the on-site workload of cold chain management personnel.It also guarantees the authority, legitimacy, and non-tampering of recorded information through blockchain certificate storage technology.The application of the electronic signature technology is compatible with technical defense and civil defense methods, and is worthy of further promotion and use.
ABSTRACT
Objective To assess the accuracy of immunization program vaccination rates through the immunization program information system by comparing immunization program vaccination rates among children between field investigation and information system sample survey in Shanghai. Methods From three districts in Shanghai， samples were stratified and randomly selected.The PPS sampling method (probability proportional to size) was used for 634 children aged 0-6 years for field investigation and 630 children aged 0-6 years were randomly selected for information system sample survey.The immunization program vaccination rates of children surveyed were investigated， statistically analyzed and compared. Results Statistically significant differences (P < 0.05) were found in the age composition and household registration composition of children sampled by the field investigation and information system sample survey.The national immunization program vaccination rate was 99.91% and timely vaccination rate was 94.29% by the field investigation.The national immunization program vaccination rate was 97.49% and timely vaccination rate was 87.90% by the information system sample survey.All 26 doses of immunization program vaccine surveyed had lower rates of coverage and timely vaccination in the information system sample survey than in the field investigation.Eighteen doses of vaccination rates by information system sample survey data were statistically significantly (P < 0.05) lower than those by field investigation and 20 doses of timely vaccination rates by information system sample survey data were statistically significantly (P < 0.05) lower than those by field investigation. Conclusion There are advantages and disadvantages to both field investigation and information system sample survey of immunization program vaccination rates.Field investigation and information system sample survey should be used in combination to evaluate the vaccination rate in future.
ABSTRACT
Objective To understand the maternal positive rate of HBsAg and the neonatal immunization in Huangpu District of Shanghai so as to provide bases for developing strategies of preventing hepatitis B and reducing the rate of neonatal hepatitis B virus infection.Methods By adopting cluster sampling research methods, retrospective surveys were conducted for the detection of HBsAg of the pregnant women from all the obstetric institutions(7 institutions) in Huangpu District of Shanghai as well as for the neonatal hepatitis B vaccinations therein from 2013 to 2015, and statistical analyses were made for the results thereof by utilizing the SPSS 20.0 software.Results A total of 29 425 pregnant women were surveyed and the positive rate of HBsAg thereof was 3.95%.The detection rate of HBsAg(98.42% & 96.76%) as well as the positive rate of HBsAg (2.58% & 4.50%) for both the local and external pregnant women in Shanghai, respectively, showed statistical differences (P<0.01).The newborns of mothers with positive rates of HBsAg who used combined immunization(HBIG+hepatitis B vaccine) amounted to 1 130, with the rate of combined immunization reaching 98.52%.Conclusion The positive rate of HBsAg for the pregnant women in Huangpu District of Shanghai is below the level thereof for those in either the whole country or the other cities and provinces, which shows that Shanghai has made effective achievements in hepatitis B vaccination as well as in the health education relevant thereto.However, active and positive combined immunization measures should still be strengthened for the newbornsof mothers with positive rates of HBsAg.In addition, with the growth of pregnant women under new policies, better maternal health care mechanism should be established and various prenatal inspections should be well implemented, thus reducing the rate of the people without taking the detection of HBsAg and preventing newborns from being infected by hepatitis B virus as a result of failing to take timely immunization measures.