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OBJECTIVE:To probe into rational use of drugs in community medical institutions of our city and to provide reference.METHODS:1106 outpatient prescriptions were collected from 12 community medical institutions in our city.Rational use of drugs was evaluated.RESULTS:There were severe irrational uses of drug in community medical institutions of our city.Especially antibiotics,hormones,vitamins abuse and excessive use of intravenous infusion phenomenon was particularly prominent.CONCLUSION:Community medical institutions should further improve understanding for the importance of rational use of drugs.Clinical pharmacists should enhance knowledge of rational use of drugs and supervision of rational use of drugs.
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OBJECTIVE:To compare the vitro dissolution between glimepiride tablets and glimepiride dropping pills.METHODS:In vitro dissolution test was conducted in accordance with the related methods specified in Chinese Pharmacopeia(2005 Edition)with the content of glimepiride determined by UV spectrophotometry.The accumulative dissolution percentages of the two formulations were computed respectively.The dissolution parameters(T50,Td,m,r)were fitted using Weibull equation and the data about the accumulative dissolution percentage were analyzed.RESULTS:There were significant differences between glimepiride tablets and glimepiride dropping pills in dissolution rate(18.70% vs.40.25% at 5 min and 90.32%vs.99.96% at 45 min,P
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OBJECTIVE:To discuss the general regularity and characteristics of the drug-induced edema so as to provide reference for clinical safe medication.METHODS:173 drug-induced edema cases publicly reported in domestic journal from 2001 to 2006 were analyzed statistically.RESULTS:The drug-induced edema was more often seen in males than in females,but not linked to age.It was characterized by early onset,with 76(43.9%)showing edema within 1h.It was chiefly induced vial oral and intravenous routes.The drug-induced edema was caused by 17 drug categories(or 115 kinds),with antibacterials showing the highest percentage(31.2%,54 cases).Laryngeal edema,which occurred in 57 cases,was the chief type among all the edema cases.CONCLUSION:Drug-induced edema is a common adverse drug reaction,which should be given great attention in the clinic,much as in the case of acute laryngeal edema.Clinicians should give close monitoring on patients after medication to guard against possible events.