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Objective:To investigate early cardiac rehabilitation program on short term and long term effect of patients with acute myocardial infarction after percutaneous coronary intervention.Methods:A total of 98 acute myocardial infarction patients who undergo percutaneous coronary intervention were randomly assiged to the study group ( n=49) and the control group ( n=49). Participants in the control group received exercise training, while the study group carried out early cardiac rehabilitation program. The cardiac function, activity of daily living and exercise endurance were compared in both groups before and 1 week after intervention, in addition, the patient`s quality of life and the incidence of adverse cardiac events were also compared before and 6 months after intervention. Results:After 1 week of intervention, the value of LVEF, LVDD, scores of activity of daily living and 6MWT were (56.74 ± 8.92)%, (49.29 ± 5.09)mm, (76.00 ± 5.95) and (378.12 ± 48.54)m in the study group, those index were (52.10 ± 7.44)%, (48.47 ± 4.04)mm, (72.93 ± 6.51), (355.69 ± 46.36)m in the control group, the LVEF, scores of activity of daily living and 6MWT were significantly increased in the study group compared to the control group ( t=0.878-2.792, P<0.05). After 6 months of intervention, the scores physical function, role-physical, bodily pain, general health, vitality, social function, role-emotional, mental health were [(75.14 ± 12.15), (56.38 ± 7.65), (68.79 ± 6.65), (68.48 ± 10.91), (80.82 ± 7.12), (66.44 ± 9.61), (77.75 ± 13.05), (77.07 ± 8.46)] and [(72.70 ± 10.97), (52.05 ± 5.61), (62.07 ± 5.51), (65.76 ± 8.45), (78.33 ± 8.71), (65.20 ± 6.84), (72.53 ± 9.66), (75.49 ± 5.76)] in the study group and control group, respectively. The scores of role-physical, bodily pain, role-emotional were significantly increased in the study group compared to the control group ( t=2.248-3.448, P<0.05). The study group showed lower incidence of angina and arrhythmia compared to the control group (4.08% and 6.12% vs 16.33% and 20.41%), the differences had statistical significance ( χ2=4.009 and 4.346, P<0.05). Conclusion:Early cardiac rehabilitation program improve the cardiac function and exercise endurance in patients with acute myocardial infarction after percutaneous coronary intervention, reduce the the incidence of adverse cardiac events and improved patients` quality of life.
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Objective To study the effect of litchi saponin and flavones on glycometabolism in insulin resistance model of HepG2 cells .Methods Using high insulin in HepG2 cells to establish a cell model of insulin resistance .Cell model was treated by litchi saponin ,litchi flavones and rosiglitazone ,respectively .Glucose concentration of cell culture supernatant was detected by glucose oxidase method .Results In the concentration of 10-6 mol/L insulin for 24 hours ,HepG2 reached the highest level of resistant to insulin ,which means a successful insulin resistance cell model was established .However ,no significant decrease in glucose concentration of cell culture supernatant was observed with litchi saponin and flavones .Conclusion This study sug-gests that litchi saponin and flavones have no effect to improve insulin resistance .
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OBJECTIVE:To develop the method for determination of the contents of protocatechuic acid in Litchi seed and its preparations.METHODS:The contents of protocatechuic acid were determined by HPLC with Spherisorb C18 column as stationary phase and acetonitrile-water(15∶18) as mobile phase and ? 260nm as detection wavelength.RESULTS:The calibration curve was linear in this experiment.The average recovery was 100% with RSD of 2%(n=5).CONCLUSION:This method is high in precision and satisfactory in isolation and repeatability,the result is accurate.It may be adopted for quality control of Litchi seed preparations.
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OBJECTIVE: To investigate the pharmacological effects of Piyangning. METHODS: To observe the pharmaco-- logical effects of Piyangning correlating with pharmacodynamics by the n1ethods of croton oil-induced ear acute inflammatory oedema, 2, 4-dinitrochlorobenzene(DNCB) induced delayed type hypersensitivity(DTH ) reaction in mice, and histamin--induced allergic pruritic tolerance in guinea pig, and bacteriostatic test in vitro. RESULTS: The results showed that croton oil - induced ear acute inflammatory oedema and DTH reaction were inhibited(P
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OBJECTIVE:To investigate the mechanism of litchi saponin in impr oving action of insulin resistance(IR)in rats with hyperlipemia-hepar adiposum.METHODS:The hyperlipemia-hepar adiposum was used to establish IR model of rats,the effects of litchi saponin,roglitazone and gliclazide on the index of fasting serum glucose(FSG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),tumor necrosis factor(TNF)-?,content of insulin,in?sulin sensitivity(ISI)and so on were observed in the model rats2hours after medication.RESULTS:Litchi saponin could sig?nificantly lower the level of FSG,TC,TG,contents of insulin and the concentration of TNF-?(P
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OBJECTIVE:To investigate the mechanism of saponin of Litchi(Sap.Lit)in reversing dexamethasone(DX)-in?duced insulin resistance(IR)in rats.METHODS:With DX-induced insulin resistant rat model,serum levels of total cholesterols(TC),triacylglycerol(TG),cortisol(Cort),fasting glucose(FSG),insulin(Fins),and index of insulin sensitivity(ISI)were detected2h after administration of drug.RESULTS:Sap.Lit reduced the levels of TC,TG,Cort,FSG,Fins(P