ABSTRACT
Objective:To explore the correlation between ascending aortic elasticity and coronary blood flow reserve (CFR)in patients with hypertension.Methods:A total of 60 patients with essential hypertension were regarded as hypertension group,another 50 normotensive subjects were enrolled as normal control group during the same period. Ascending aortic dilation (D),stiffness (β)and CFR were measured and calculated by tissue Doppler ultrasound,then compared between two groups.Pearson correlation analysis was used to analyze the correlation amongβ,D and CFR.Results:Compared with normal control group,there were significant reductions in D [(3.59±0.30)10-6 cm2/d vs.(2.88±0.77)10-6 cm2/d]and CFR [(3.23±1.16)vs.(2.02±0.63)],and significant rise inβ[(3.54 ±1.52)vs.(5.46±1.98)]in hypertension group,P<0.05 or<0.01. Pearson correlation analysis indicated thatβwas significant inversely correlated with CFR (r=-0.413,P=0.005),while D was significant positively correla- ted with CFR (r=0.384,P=0.003 ).Conclusion:Reduced ascending aortic elasticity is significantly correlated with coronary blood flow reserve.
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Objective:To explore clinical features of aged patients with coronary heart disease (CHD)and normal resting electrocardiogram (ECG).Methods:The data of coronary angiography results and its risk factors were ret-rospectively analyzed in 46 aged CHD patients with normal resting ECG.Results:In the 46 patients,there were 18 cases (39.1%)with single-vessel coronary disease and 28 cases (60.9%)with multi-vessel coronary disease;32 cases with left anterior descending artery disease,22 cases with right coronary artery disease,16 cases with left circumflex coronary artery disease and two cases with left main disease.Compared with single vessel coronary disease group, there were significant rise in percentage of patients complicated with diabetes mellitus (33.3% vs.75.0%)and chronic kidney disease (22.2% vs.53.6%)in multi-vessel coronary disease group,P <0.05 both.Conclusion: Multi-vessel coronary disease is frequent,and percentages of patients complicated with diabetes mellitus and chronic kidney disease are higher in aged patients with coronary heart disease and normal resting electrocardiogram.
ABSTRACT
Objective To study the relationship of single nucleotide polymorphism of angiotensin converting enzyme 2 ( ACE2 ) with essential hypertension(EH) and antihypertensive response of valsartan.Methods A total of 120 case EH patients was received valsartan once daily for four weeks.Direct DNA sequencing was performed to detect the signgle nucleotide polymorphisms of ACE2 in 120 EH patients and 60 controls with normal blood pressure.ResultsThe genotyping data indicated that there were significant differences of G allele frequency between male or female EH group and controls( x2 =5.310,4.423,P ＜0.05 ).Treated with valsartan,patients with.G allele were not found to be associated with reduction in blood pressure( P ＞0.05).Conclusions Our data suggest that the ACE2 G8790A signgle nucleotide polymorphisms might be involved in the development of EH.The risk developing hypertension in the people carrying G allele is higher than that in those carrying other allele.Therefore,ACE2 gene might be a sensitive gene associated with EH.