ABSTRACT
Objective:To investigate the relationship between risk factors including leukoaraiosis(LA)and recurrent ischemic stroke.Methods:A total of 751 patients with first-episode acute ischemic stroke hospitalized within 72 h of onset in the Department of Health and Neurology of our hospital from January 2010 to December 2014 were consecutively selected and followed up for 3 years.Eventually, 701 patients were included in the study, with 124 patients with recurrence in the recurrence group and 577 patients without recurrence in the non-recurrence group.Associated risk factors were compared and analyzed between the two groups.Results:The severity of LA in the recurrence group was significantly greater than that in the non-recurrence group( Z=-2.307, P=0.021). The rates of successful control of blood glucose, blood pressure and blood lipids in the recurrence group were significantly lower than those in the non-recurrence group, (all P<0.05). Pearson correlation analysis showed that factors positively correlated with ischemic stroke recurrence were LA( r=0.451, P=0.007), age( r=0.334, P=0.015), blood pressure( r=0.812, P=0.001), blood glucose( r=0.637, P=0.002), low density lipoprotein cholesterol(LDL-C)( r=0.674, P=0.000), total cholesterol( r=0.748, P=0.003), triacylg lycerol( r=0.878, P=0.004)and smoking( r=0.380, P=0.008), and one factor not significantly correlated with ischemic stroke recurrence was gender( r=0.032, P=0.115). The binary-class logistic regression analysis showed that factors positively correlated with ischemic stroke recurrence included age( B=0.142, P=0.000), blood pressure( B=0.135, P=0.000), LDL-C( B=1.141, P=0.001), triacylg lycerol( B=0.367, P=0.036)and blood glucose( B=0.385, P=0.000); factors not significantly correlated with ischemic stroke recurrence included LA( B=22.221, P=0.997), total cholesterol( B=0.081, P=0.867)and smoking( B=21.434, P=0.995). Conclusions:Age, hyperglycemia, hypertension and triacy lglycerol are independent risk factors and LA, total cholesterol and smoking are confounding factors for ischemic stroke recurrence.Active intervention is of great significance for preventing the recurrence of ischemic stroke.
ABSTRACT
Objective To explore the correlation between the recurrence rate of the elderly patients with lacunar infarction and the risk factors including blood pressure, blood glucose, total cholesterol, triglycerides,low density lipoprotein cholesterol values, high-density lipoprotein cholesterol and other. Methods 207 over 60 years old patients with lacunar infarction occurred the first time were included in the study. All patients were followed up two years to assess the relapse rate and the risk factors of the patients with lacunar infarction. Results 207 cases of elderly patients with lacunar infarction complicated with hypertension,type 2 diabetes and hyperlipidemia were 148 cases,22 cases,7 cases respectively, and the recurrence rates of three groups were 8.78%, 18.18%, 14.29% respectively;The patients complicated with hypertension and 2 type diabetes were 6 cases,and the recurrence rate was 34.62%;The patients without hypertension,type 2 diabetes and hyperlipidemia were 4 cases,and the recurrence rate was 0%. In two years,27 cases of lacunar infarction recurred,and the recurrence rate was 13.04%. Conclusion Hypertension,type 2 diabetes,hyperlipidemia could also be considered as the high-risk predictor factors for the recurrence rate of the elderly patients with lacunar infarction.