Disease spectrum and causes of death in hospitalized children in an upper first-class hospital in Hunan Province, China, from 2010 to 2014 / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the disease spectrum and causes of death in hospitalized children in an upper first-class hospital in Hunan Province, China.</p><p><b>METHODS</b>The medical records of hospitalized children between 2010 and 2014 in this hospital were collected and analyzed retrospectively.</p><p><b>RESULTS</b>From 2010 to 2014, the number of hospitalized children increased from 7 303 in 2010 to 10 902 in 2014, and the case fatality rate declined from 0.33% to 0.20% (P<0.05). The case fatality rate was highest (0.41%) in infants and lowest (0.11%) in newborns. As for the disease spectrum for these hospitalized children, in 2010, the top three diseases were leukemia, congenital heart disease, and pneumonia; in 2011, the top three diseases were tumor chemotherapy, congenital heart disease, and pneumonia; since 2012, tumor chemotherapy, epilepsy, and pneumonia had remained the top three diseases. The top three causes of death in hospitalized children were congenital malformation (39%, 39/99), tumor (13%, 13/99), and infectious diseases/parasitic diseases (8%, 8/99).</p><p><b>CONCLUSIONS</b>The number of hospitalized children is increasing, while the case fatality rate tends to decrease in this hospital. Tumor, epilepsy, pneumonia, and congenital heart disease are major diseases in hospitalized children, and congenital malformation is the primary cause of death.</p>

Study the effects of flavonoids of Rhizoma Drynariae on gene level of rats without ovaries by technology of cDNA array / 中国中药杂志

<p><b>OBJECTIVE</b>To study the effects of flavonoids of Rhizoma Drynariae on gene level of rats without ovaries (OP) by technology of cDNA array.</p><p><b>METHOD</b>The models of rats without ovaries were made After. 24 weeks of treatment, put them to death and sampled 6 ml blood from the abdominal aorta and 4cm spinal cord. Take out the total RNA, then separate the mRNA to check.</p><p><b>RESULT</b>There is 70 genes difference between the blank control group and model group, 9 genes difference between the blank control group and flavonoids of Rhizoma Drynariae group. The genes over expression of OP rats models regain normal after the models were fed on flavonoids of Rhizoma Drynariae. There are no differences in the spinal cords genes in the cDNA array analysis of this trail.</p><p><b>CONCLUSION</b>The genes over expression of OP rats models regain normal after the models were fed on flavonoids of Rhizoma Drynariae for 6 months. The result shows that the flavonoids of Rhizoma Drynariae does have certain effects on the gene expression of rats without ovaries.</p>