Innate immune receptors mediated neuroinflammation in nervous system diseases / 中国药理学与毒理学杂志

Neuroinflammation is closely associated with the development of neurodegeneration diseases, mental disorders and brain injuries. Innate immunity receptors are the first defense line against infections and injuries, which play a critical role in the neuroinflammation and nervous system diseases.This review,focuses on the type classification,function,regulatory mechanism for the innate immunity receptors,and illustrates their roles and molecular mechanism in the development of neuroin-flammation and nervous system diseases.In addition,we will review the current drugs for treating related nervous system diseases, and the possibility of developing new drugs that target neuroinflammation and using anti-inflammatory drugs clinically.