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Objective To study the efficacy and safety of carotid artery stenting(CAS) in elderly patients with internal carotid artery stenosis and its related factors.Methods Between January 2012 and July 2014,a total of 152 patients(over 65 years of age)with carotid artery stenosis were enrolled in this study,of whom 79 patients received drug treatment (control group) and 73 patients received CAS (intervention group).The two groups were followed up for one year.The patients'' scores of mRS(the modified Rankin Scale) and NIHSS(the National Institute of Health Stroke Scale) were observed and compared in the curative effect between the two groups.By means of logistic regression were analyzed the related safety factors in CAS treatment for elderly patients over 65 with extracranial stenosis of internal carotid artery.Results Both the median mRS (P<0.01) and NIHSS(P<0.05) scores were lower in intervention group than those in control group at 3,6 and 12 months follow-up,respectively.Thirty days after CAS,there occurred transient ischemic attack (TIA) in intervention group,whose incidence was significantly lower than that in control group (P<0.05).However,there was no statistical significant difference found between the two groups in the incidence of serious adverse events including TIA,cerebral hemorrhage,cerebral infarction and death(P>0.05)at one year follow-up.And logistic regression analysis showed that the previous history of cerebral infarction,residual stenosis or combined un-interferential cerebral arterial stenosis were all independent predictors of serious adverse events including TIA,cerebral infarction,cerebral hemorrhage,re-stenosis and death (P<0.05).Conclusion CAS is a safe and effective procedure for old patients with internal carotid artery stenosis.A history of cerebral infarction,combined un-interferential cerebral arterial stenosis or residual stenosis after CAS were all risk factors,which need to be effectively controlled before CAS.
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<p><b>OBJECTIVE</b>To investigate regulative effect of electroacupuncture (EA) of different frequencies on derangement of gastric electric rhythm in rabbits.</p><p><b>METHODS</b>Derangement of gastric electric rhythm model was made with injection of erythromycin into ear vein in 40 rabbits, and randomly divided into a model group, a 3 Hz-EA group, a 20 Hz-EA group and a 100 Hz-EA group. They were treated with EA at Zusanli (ST 36) with 3 Hz, 20 Hz and 100 Hz, respectively. PDP and PTP at different periods were detected with IEGG spectrum analyzer.</p><p><b>RESULTS</b>Erythromycin could significantly enhance PDP and PTP values in the rabbit (P < 0.001). PDP and PTP values were reduced significantly after EA with 3 Hz, 20 Hz and 100 Hz (P < 0.05), with no significant differences in effect on PDP among them (P > 0.05); therapeutic effect of the EA of 20 Hz on PTP was better than that of 3 Hz (P < 0.05), with no significant difference as compared with the EA of 100 Hz.</p><p><b>CONCLUSION</b>EA of the 3 frequencies shows significantly different regulative effects on derangement of gastric electric rhythm in rabbits.</p>
Subject(s)
Animals , Female , Male , Rabbits , Electroacupuncture , Erythromycin , Pharmacology , Gastrointestinal Motility , Stomach , PhysiologyABSTRACT
Aim To observe homoharringtonine(HHT) distribution in eyeball tissue of rabbit. Methods Harringtonine(HT) was used as internal standard. The chromatography consisted of Kromasil C18 column with methanol 0.01mol?L-1 (60∶40,pH 2.5) as the mobile phase at the flow rate of 0.8ml?min-1. Results The chromatography retention time of HHT and HT were 6.35min and 4.70min. The standard curve was linear in the concentration range of 5～200 ?g?L-1 in serum and the relation coefficient was 0.994. The recovery of spiked sample was(93.17?4.31)%. After injection of 2mg of HHT in side of rabbit eyeball, the contents in sclera, cornea, retina, vitreous body and crystalline lens were reduced progressively, but the eliminate rate were reduced in a proper order. Conclusion HHT can distribute to every eyeball tissue when it was injected in side of rabbit eyeball.