ABSTRACT
Objective To observe the therapeutic effect of ziprasidone and risperidone on patients with schizophrenia,and analyze the influence on metabolism.Methods 124 patients with schizophrenia were selected and randomly divided into two groups,with 62 cases in each group.They were treated with either ziprasidone or risperidone for both 12 weeks.The PANSS score was compared at the baseline,2 weeks,4 weeks,8 weeks and 12 weeks after ther-apy.The FBG,FINS,HOMA-IR,TG,LDL-C,HDL-C,BMI and prolactin were compared before and after treatment. Results There were 57 and 55 cases completed the study,respectively.There was no difference in PANSS score between 2 groups before and after treatment (P >0.05),although both ziprasidone and risperidone could significantly decrease PANSS (t =6.132,10.323,18.252,23.564,all P 0.05).After treatment,the levels of FBG, FINS,HOMA-IR,TG,BMI and prolactin in ziprasidone group were all significantly increased (t =3.837,12.729, 13.767,4.512,3.176,17.308,all P 0.05).However,there were significant differences between the two groups in FBG,FINS,HOMA-IR,TG, BMI and prolactin after treatment (t =2.511,4.193,7.671,4.439,3.224,16.663,all P <0.05 ).Conclusion Ziprasidone and risperidone both contribute to the alleviation of symptoms in schizophrenia,while ziprasidone has less influence on glucose-lipid metabolism.