ABSTRACT
Objective:To investigate the effect of Portulacae Herba free granules on the degree of lens opacity and integrin β1 of lens in diabetic cataract rats. Methods:50 rats were randomly divided into control group, model group and the low, medium and high dose group of Portulacae Herba, 10 rats in each group. Except the control group, the diabetic cataract rat model was established by intraperitoneal injection of 1% STZ 60 mg/kg. The low, medium and high dose groups of Portulacae Herba were gavaged with Portulacae Herba 125, 250, 500 mg/kg, once a day for 12 weeks. The degree of lens opacity was observed with slit lamp. After 12 weeks, the lens was stained with HE. The expression of integrin β1 was detected by Western blot.Results:Compared with the model group, the opacification degree of lens in the low, medium and high dose groups of Portulacae Herba was significantly decreased ( P<0.05), the expression of integrin β1 (1.58 ± 0.14, 1.46 ± 0.24, 1.12 ± 0.19 vs. 1.76 ± 0.23) in rat lens was decreased ( P<0.05). Conclusion:For diabetic cataract rats, Portulacae Herba free granules can influence the expression of integrin β1 and inhibit the occurance of lens opacity.
ABSTRACT
[Objective] To observe the therapeutic effect of puerain with corticosteroid on nonanterior ischmic optic neuropathy (NAION).[Methods] In 58 patients(60 eyes)who were diagnosed as NA10N,29 patients (30 eyes)underwent intravenous drip with puerain and corticosteroid (treatment group);and the other 29 patients (3o eyes)underwent intravenous drip with corticosteroid and compound anisondine (control group).[Results] The visual acuity was better in treatment group than that in control group with a significant difference (x2=4.83,P