ABSTRACT
Objective The Rothman-Keller model was used to establish a predictive model for the risk of birth defects on the basis of evidence-based medicine, which so as to provide the basis for pertinent interventions in China. Methods First, the odds ratio (OR) value of risk factors for birth defects was obtained by evaluating the literature of meta-analysis, and the risk score table of the Rothman-Keller model was constructed. Then the simulation data was used to build the model, the risk boundary value of risk prediction, and finally the actual data to was used for verification. Results The main risk factors for 20 birth defects were collected through 17 articles. In the actual data of Shanxi Province, the actual incidence rate of high-risk populations screened by Rothman-Keller model was 10.9%, and it was statistically different from other groups ( 2 =147.58，P<0.001). In addition, the rothman-keller model identified all patients with a family history of birth defects as high-risk. Conclusions Through the meta-analysis literature on birth defects in China, the study find the main risk factors and construct a risk prediction model. It can be used to predict the risk of birth defects and help screen high-risk groups. At the same time, it provides ideas for predicting the risk of other diseases.
ABSTRACT
<p><b>OBJECTIVE</b>To observe the influence of different frequencies of acupuncture on the therapeutic effect in patients with cerebral infarction at convalescence.</p><p><b>METHODS</b>Ninety-seven cases were randomly divided into an observation group I (n = 50) and an observation group II (n = 47). They were treated with same Chinese drugs and western medicine and electroacupuncture at Jiquan (HT 1), Quchi (LI 11), Hegu (LI 4), Huantiao (GB 30), etc. The observation group I was treated twice each day and the observation group II once each day. After treatment of 30 days, their therapeutic effects were observed.</p><p><b>RESULTS</b>The total effective rate of 94.0% for improvement of limb activity in the observation group I was better than 78.7% in the observation group II (P < 0.05); the therapeutic effects for choking when taking water, dysphagia, vague mind and slurred speech were similar in the two groups (P > 0.05).</p><p><b>CONCLUSION</b>The therapeutic effect of acupuncture twice each day on cerebral infarction at convalescence is superior to that of once daily.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Acupuncture Therapy , Methods , Cerebral Infarction , Drug Therapy , Therapeutics , Combined Modality Therapy , Convalescence , Drugs, Chinese Herbal , Therapeutic Uses , Treatment OutcomeABSTRACT
<p><b>AIM</b>To search for colchicine derivatives which have high efficacy and low toxicity.</p><p><b>METHODS</b>Colchicine was firstly converted into thiocolchicine, and then it was hydrolyzed to get 7-(N-deacetylthiocolchicine). At last, 7-(N-deacetylthiocolchicine) was amidated to get the target compounds. The chemical structure of these new derivatives was confirmed with 1H NMR, IR, MS, and HR-MS. The cytotoxicity of the compounds was tested by MTT assay. Their in vivo antitumor activity was evaluated against mice tumor H22 and U14.</p><p><b>RESULTS</b>Twelve thiocolchicine derivatives are new compounds.</p><p><b>CONCLUSION</b>In vitro antitumor activity has showed that some of these thiocolchicines possessed cytotoxic activity superior to colchicine. However, in vivo antitumor activity indicated that these derivatives have poor efficacy in mice.</p>
Subject(s)
Animals , Humans , Male , Mice , Antineoplastic Agents, Phytogenic , Chemistry , Pharmacology , Cell Line, Tumor , Cell Survival , Colchicine , Chemistry , Pharmacology , Inhibitory Concentration 50 , Liver Neoplasms, Experimental , Pathology , Mice, Inbred ICR , Models, Chemical , Molecular Structure , Neoplasm Transplantation , Prostatic Neoplasms , Pathology , Structure-Activity RelationshipABSTRACT
Objective:To study the antimalarial mechanism of benflumetol (B). Methods: Flow cytometry (FCM) was used to analyze the effects of B and chloroquine (CQ) on DNA content of Plasmodium berghei and pH value of the lysosome of malarial parasites. Results: DNA content of the plasmodia not treated with any drugs was not changed in 24 hours,while benflumetol could decrease the DNA content: the DNA content began to decrease 2 h after the drug administration and reached the minimum by 16 h, but somewhat increased at 24 h after administration. The pH in the lysosome increased 1 h and restored premedication level 4 h after benflumetol administration. Chloroquine had the same effects on DNA and lysosome pH of malarial parasites.Conclusions: The antimalarial mechanism of benflumetol is directly related to its effect to inhibit the synthesis of DNA.