ABSTRACT
Objective To evaluate the efficacy of modified Xuefu-Zhuyu decoction in the treatment of nonarteritic anterior ischemic optic neuropathy (NAION).Methods A total of 87 patients with NAION who met the inclusion criteria were divided into control group (43 cases) and study group (44 cases) by the random number table method.The control group was given the routine treatment combined with compound anisodine injection,while the study group was treated with routine treatment combined with modified Xuefu-Zhuyu decoction.Both groups were treated for 28 days.The standard logarithmic visual acuity chart was used to detect and record the best corrected visual acuity.The Visual field photosensitivity and visual field defect was recorded by visual field program(Oc-topus-101).The systolic peak blood flow velocity (PSV),end diastolic velocity (EDV),resistance index (RI) of the posterior ciliary short artery were measured by color Doppler ultrasound.The clinical effect was evaluated.Results The total effective rate was 97.7％ (43/44) in the study group and 76.7％ (33/43) in the control group.There were significant differences between the two groups (x2=8.669,P=0.003).After treatment,the best corrected visual acuity (0.85 ± 0.21 vs.0.72 ± 0.32,t=2.245),visual field photosensitivity (18.71 ± 4.79 φ/db vs.16.32 ± 5.22 φ/db,t=2.226) in the study group was significantly higher than those in the control group (P＜0.05);the visual field defect (6.06 ± 1.52 φ/db vs.8.13 ± 2.43 φ/db,t=4.775) in the study group was significantly lower than that of the control group (P＜0.05);the PSV (10.03 ± 1.79 cm/s vs.8.85 ± 1.88 cm/s,t=2.999),EDV (3.06 ± 0.37 crn/s vs.2.67 ± 0.31 cm/s,t=5.323) in the study group was significantly higher than those of the control group (P＜0.05),RI (0.61 ± 0.08 vs.0.69 ± 0.09,t=4.385) in the study group was significantly lower than that of control group (P＜0.05).Conclusions The modified Xuefu-Zhuyu decoction combined with conventional medicine can effectively improve the hemodynamics and visual function of posterior ciliary short artery in NAION patients and improve the clinical efficacy.