ABSTRACT
Objective To observe the effect of Ruzengping granule on mammary gland of rat with mastoplasia. Methods After benzoate estradiol and progestogen had been injected into rats for 35 days, the mastoplasia model was made. The model rats were treated with Ruzengping granule for 30 days, to measure the mammary papilla diameter of the rats in all groups, to observe morphologic changes of mammary papilla and the changes of mammary gland under microscope, to determine the content of estradiol in blood serum and blood rheology by radio-immunity. Results Ruzengping granule could significantly inhibit the mammary papilla's diameter of the mastoplasia rats, lessen mammary papilla’s symptoms in morphology, reduce the quantity of lobule of mammary gland, lobule-alveolus in mammary gland and the diameter of acinar lumina. Ruzengping granule could also significantly improve blood rheological nature and degrade content of estradiol in blood serum. Conclusion Ruzengping granule can healing efficaciously rat’s mastoplasia induced by benzoate estradiol.
ABSTRACT
AIM: To observe the effects of diosgenin on enhancing efficacy and reducing toxicity of FT-207 in tumor-bearing mice. METHODS: The inhibitory rate on tumor growth and immune function of the in tumor-bearing mice model of transplanting MFC,HepA,H_22 and S_180 tumor were measured. RESULTS: Diosgenin had significant restraining effects on MFC in mouse.It could enhance the activity of macrophage and the level of serum hemolysin. CONCLUSION: Diosgenin can enhance the anti-tumor effect of FT-207.It can also improve the immunological function and reduce the adverse reactions of chemotherapy.