ABSTRACT
Objective To investigate effect of curcumin on NT-pro-BNP, IL-6, IL-10 and pulmonary function in patients with sepsis induced by lung injury.Methods 40 patients with purulent septic lung injury were collected in the hospital and divided into control group and experimental group according to different treatment, 20 cases in each group.The control group were given conventional treatment and the experimental group were given curcumin capsule on the basis of control group for a consecutive treatment of one weeks.After treatment, the serum levels of NT-pro-BNP, IL-6, IL-10 and pulmonary function were detected of two groups.ResuIts Compared with control group after treatment, serum IL-6 and IL-10 levels of patients in experimental group decreased significantly ( P<0.05 ) , serum NT-pro-BNP levels in experimental group decreased significantly ( P<0.05 ) , vital capacity (VC), maximal voluntary ventilation (MVV), and forced expiratory volume in one second (FEV1) levels in experimental group increased significantly (P<0.05).ConcIusion Curcumin could significantly reduce serum NT-pro-BNP, IL-10 and IL-6 levels in patients with lung injury, improve the pulmonary function, and has a guiding significance for clinical use.
ABSTRACT
Objective To evaluate the clinical effect and safety of transcatheter thrombus-breaking combined with local infusion of reteplase (rPA) in treating severe pulmonary thromboembolism (PTE). Methods During the period from June 2010 to June 2013 at authors’ hospital, transcatheter thrombus-breaking combined with local infusion of reteplase was carried out in 26 patients (17 males and 9 females) with severe pulmonary embolism. The changes of pulmonary circulation and the cardio - pulmonary hemodynamics after the treatment were analyzed. Results The preoperative mean pulmonary artery pressure, arterial blood oxygen partial pressure and the blood pressure were (63.78 ± 6.89) mmHg, (73.23 ± 11.51) mmHg and (87.35 ± 10.92) mmHg respectively, while the postoperative ones were (26.23 ± 10.27) mmHg, (93.48 ± 6.17) mmHg and(127.14 ± 13.15) mmHg respectively, and the differences between preoperative and postoperative ones were statistically significant (P<0.01). All the patients were followed up for 6 - 36 months. Significant stable clinical improvement was obtained in 25 patients, and recurrence was seen in one patient. Conclusion Transcatheter thrombus-breaking combined with local infusion of reteplase can quickly improve the pulmonary circulation and the clinical conditions for patients with severe pulmonary thromboembolism, and it has no obvious complications. This technique carries excellent value in maintaining the stability of hemodynamics.