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Objective@#To observe the effects of arnebia root oil on wound healing of rats with full-thickness skin defect, and to explore the related mechanism.@*Methods@#Eighty SD rats were divided into arnebia root oil group and control group according to the random number table, with 40 rats in each group, then full-thickness skin wounds with area of 3 cm×3 cm were inflicted on the back of each rat. Wounds of rats in arnebia root oil group and control group were treated with sterile medical gauze and bandage package infiltrated with arnebia root oil gauze or Vaseline gauze, respectively, with dressing change of once every two days. On post injury day (PID) 3, 7, 14, and 21, 10 rats in each group were sacrificed respectively for general observation and calculation of wound healing rate. The tissue samples of unhealed wound were collected for observation of histomorphological change with HE staining, observation of expressions of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) with immunohistochemical staining, and determination of mRNA expressions of VEGF and bFGF with real time fluorescent quantitive reverse transcription polymerase chain reaction. Data were processed with analysis of variance of factorial design, t test, and Bonferroni correction.@*Results@#(1) On PID 3, there were a few secretions in wounds of rats in the two groups. On PID 7, there were fewer secretions and more granulation tissue in wounds of rats in arnebia root oil group, while there were more secretions and less granulation tissue in wounds of rats in control group. On PID 14, most of the wounds of rats in arnebia root oil group were healed and there was much red granulation tissue in unhealed wounds, while part of wounds of rats in control group was healed and there were a few secretions and less granulation tissue in unhealed wounds. On PID 21, wounds of rats in arnebia root oil group were basically healed, while there were still some unhealed wounds of rats in control group. (2) On PID 3 and 7, the wound healing rates of rats in arnebia root oil group were (39±5)% and (46±4)% respectively, which were close to (34±3)% and (44±4)% of rats in control group (with t values respectively 0.807 and 0.481, P values above 0.05). On PID 14 and 21, the wound healing rates of rats in arnebia root oil group were (76±4)% and (90±3)% respectively, which were significantly higher than (60±6)% and (73±5)% of rats in control group (with t values respectively 2.308 and 3.072, P<0.05 or P<0.01). (3) On PID 3, 7, and 14, granulation tissue, fibroblasts, and nascent capillaries in unhealed wound tissue of rats in the two groups both gradually increased, and more ranulation tissue, fibroblasts, and nascent capillaries were seen in unhealed wound tissue of rats in arnebia root oil group. On PID 21, granulation tissue, fibroblasts, and nascent capillaries in unhealed wound tissue of rats in the two groups both gradually decreased. (4) On PID 3, 7, and 14, the numbers of VEGF positive cells and bFGF positive cells in unhealed wound tissue of rats in the two groups both gradually increased; there were more VEGF positive cells and bFGF positive cells in unhealed wound tissue of rats in arnebia root oil group than those in control group. On PID 21, positive expressions of VEGF and bFGF both decreased in unhealed wound tissue of rats in the two groups. (5) On PID 3, 7, and 14, mRNA expressions of VEGF in unhealed wound tissue of rats in arnebia root oil group were higher than those of control group (with t values from 2.967 to 4.173, P values below 0.01). On PID 21, mRNA expression of VEGF in unhealed wound tissue of rats in arnebia root oil group was lower than that of control group (t=-4.786, P<0.001). From PID 3 to 21, mRNA expressions of bFGF in unhealed wound tissue of rats in arnebia root oil group were higher than those of control group (with t values from 2.326 to 4.702, P<0.05 or P<0.01).@*Conclusions@#Arnebia root oil can promote wound healing of rats with full-thickness skin defect, which may relate to increasing expressions of VEGF and bFGF.
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Objective To discuss the influence of framing information and time window information upon risk decision making about thrombolysis therapy in patients with cerebral infarction or their relatives in the scenarios of thrombolytic therapy for acute cerebral infarction.Methods Inpatients and outpatients with cerebral infarction or their relatives(n=327) were randomly divided into positive framing group(n=187) and negative framing group(n=140).Every participant underwent risky messages about thrombolytic treatment in three different time windows:0-90 minutes,91-180 minutes and 181-270 minutes.Results In any thrombolytic time window condition,there was no significant difference in thrombolytic tendency of participants between the positive framing group and the negative framing group (0-90 min:x2=1.24,P＞ 0.05;91-180 minutes:x2 =0.35,P＞0.05;181-270 minutes:x2 =0.07,P＞ 0.05).In a negative framework conditions,compared with the participants receiving thrombolytic information in 181-270 minutes time window,subjects receiving thrombolytic information in 0-90 minutes window were more tolerant of thrombolytic treatment (69.3 ％ vs 51.5 ％,P＜ 0.0125).Conclusion There are mutual effects of time window and framing information upon participants' preferences for thrombolysis.Different thrombolytic information are presented according to their corresponding time windows.
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Asthma is the most common chronic inflammatory airway disease in childhood. Adhering to a daily anti-inflammatory treatment is the most important cornerstone of bronchial asthma control. However,with the large number of clinical studies conducted in recent years,learning inhaled corticosteroids as an anti-inflam-matory drug of choice,there is a mixed compliance rate of inhaled corticosteroids in children. Standard treatment and control of asthma has yet to be further improved. This review discusses the medication adherence to long-term inhaled corticosteroid as well as the relevant aspects of research progress.
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Objective Influence of cover statement and clarity of the messages upon risk decision making about thrombolysis therapy in patients with cerebral infarction was discussed in the Scenarios of thrombolytic therapy for acute cerebral infarction.Methods Inpatients and outpatients with cerebral infarction were randomly divided into two groups:detailed / simple cover statement group.Every participant underwent obscure messages and clear messages with only one frame:positive or negative frame.Results In the simple cover statement group,both obscure messages subgroup and clear messages subgroup were not influenced by the framing effect with preference to the risk seeking.In the detailed cover statement group,participants in the clear messages group were not influenced by the framing effect(x 2 =0.19,P＞0.05),while the subjects in the obscure messages group were actually affected by the framing effect,with the preference to risk seeking in the positive framework (x 2=7.90,P＜0.01).Conclusion The risk decision making about thrombolysis therapy in patients with cerebral infarction is influenced by cover statements and clarity of the messages.To improve the rate of thrombolysis therapy,the patients should be exposed to the obscure messages in the positive framing information under the detailed cover statement.
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In this paper, a novel registration method is presented for three-dimensional mapping of cardiac chambers and computed tomography (CT) segmented surfaces. The proposed method applies random perturbations to three-dimensional mapping of cardiac chambers in order to move out of local minima. It effectively solves the problem of the existing algorithm based on iterative closest point (ICP) in which the optimization often falls into local minima, and improves the registration accuracy and success rate. The registration experiment results show that the final registration accuracy and success rate of the proposed method are better than the existing ICP-based algorithm, and it can implement the registration when the three-dimensional mapping of cardiac chambers and CT segmented surface have a wide range of initial offset.
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Humans , Algorithms , Heart , Diagnostic Imaging , Image Processing, Computer-Assisted , Methods , Imaging, Three-Dimensional , Pattern Recognition, Automated , Methods , Tomography, X-Ray Computed , MethodsABSTRACT
Objective To compare the cognitive difference of subjects'responses to the same visual stimuli under two different priming conditions,and to discuss the influence of inversion effect and configural changes upon facial recognition.Methods Priming pattern was employed,and subjects were induced to recognize the same stimuli as schematic faces or three English letters under different priming conditions.The participants'accuracy and reaction times were compared in two priming conditions. Results Participants'accuracy of the comparison stimuli in facial priming condition decreased significantly by inversion effect((79.03±10.53)%vs(89.43±9.98)%,P0.05).Correlations of accuracy to reaction times reached no significant difference under two conditions.Conclusion Priming effect make sense in the cognition,and there was a priming stage before the facial configuration.Inversion effect shows up in the face priming condition,and vanish in the English letter priming condition,which demonstrate the importance of configuration and inversion effect in the facial cognition.What's more,such effect can't be explained by the changes of cognitive difficulty.
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Objective:To study the characteristic of P300 elicited by the Oddball pattern among the depressed patients.Methods:Twelve untreated young depressed patients and sixteen normal people as a control group participated.Auditory P300 and novel P300 were induced and recorded under the Oddball pattern.Results:The depressed patients’ reaction time(755?244ms) to the target stimuli was significantly longer than that of the control group(386?114ms).As compared with the normal,the depressed patients’ amplitudes of P3b in the parietal(P
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Objective:To explore the change of attentive characteristics and subjective evaluation of mental fatigue un-der the condition of driving simulation.Methods:16 healthy taxi drivers(all males) were involved in this research.The change of attentive characteristics and the self-rating scale for subjective fatigue symptoms were both recorded before and after six-hour driving simulation.Because of the own control design,the drivers' attentive characteristics and self-rating scales were measured again in their off days.Results:There was significant difference in the changes of attentive charac-teristics in the experimental group,but no significant difference in the control group.And there was no significant differ-ence of subjective evaluation either in the experimental group or control group.Conclusion:Under the condition of driv-ing simulation,the attentive characteristics of drivers were changed,say,they were impaired,even though they did not per-ceive the feelings of fatigue.