ABSTRACT
Objective:To investigate the effects of dyslipidemia on early insulin secretion and insulin resistance in patients with type 2 diabetes mellitus(T2DM).Methods:93 newly diagnosed T2DM patients without lipid-lowering and anti-hyperglycemia therapies were divided into 3 groups by plasma lipids levels:normal lipids(group B),single high triglycerides(group C),and high triglycerides and high total cholesterol with or without low HDL-cholesterol or high LDL-cholesterol(group D).20 non-diabetic normal lipids subjects were healthy control group(group A).Early insulin secretion indexes(?I30/?G30)and insulin resistance indexes(HOMA-IR)taken from the oral glucose tolerance test were measured and analyzed.Results:Compared with healthy control subjects(group A),patients with T2DM(group B,C and D)had a significantly lower ?I30/?G30(P=0.0000,
ABSTRACT
<p><b>BACKGROUND</b>To explore the applicable value of transbronchial needle aspiration (TBNA) in the bronchial submucosa.</p><p><b>METHODS</b>TBNA biopsy was performed in 76 cases of pulmonary diseases, which had no endoscopically visible pathologic change. The results of TBNA were compared with that of brushing for cytological examination.</p><p><b>RESULTS</b>The correct diagnosis of the pulmonary diseases was 85.5% (65/76) for TBNA and 55.3%(42/76) for brushing cytology, and the correct diagnosis of lung cancer was 78.0%(39/50) for TBNA, 38.0% (19/50) for brushing cytology. Slight bleeding at the penestrated site was observed in 52 patients and there were no other severe complications.</p><p><b>CONCLUSIONS</b>TBNA is a safe, simple and effective method in clinical application and could be used widely.</p>