ABSTRACT
OBJECTIVE@#To explore the clinical use of sieving detection among the childhood with allergic disease.@*METHOD@#The sieving detection about allergen inhalant allergens, Fx5 in the CAP anaphylactogen detection system, and serum specific IgE were detected in three hundred and thirty-one cases of children (aged from 1 year to 14 years old) with allergic disease. Patients were divided into group 1, group 2 and group 3 according to the age from 0 to 3, 3 to 6, and 6 to 14 years old. All datas were statistical analysed among different age groups.@*RESULT@#Among the 331 patients, the positive rate of allergic sieving detection was 67.98%, the elevation rate of IgE was 53.78%. Inhalant allergen positive rate was 60.42%, while the food allergen positive rate was 28.10%. Inhalant allergen positive rate of the group 3 (aged from 6 to 14 years old) was significant higher than the other two age groups (68.45%). And the food allergen positive rate of the age group 1 (aged from 0 to 3 years old) was significant higher than the other two age groups (62.50%). Positive rate for simply inhalant allergen was 39.88%, while positive rate for simply food allergen was 7.55% and mixed allergen was 20.54%.@*CONCLUSION@#Inhalant allergen was the main allergen of the children with allergic disease aged over 3 years old, while food allergen was the main allergen of the children with allergic disease aged below 3 years old. It was safe, sensible and effective to use Uni CAP anaphylactogen detection system for rapid assay of specific allergens.
Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Allergens , Blood , Allergy and Immunology , Hypersensitivity , Blood , Diagnosis , Allergy and Immunology , Immunoglobulin E , BloodABSTRACT
OBJECTIVE@#In order provide important evidences for epidemiologic survey, clinical diagnosis, treatment and preservation of allergic diseases in this area, we investigate the distribution of the common allergens in allergic rhinitis and allergic asthma in Jingmen area and the sensitization condition of the major allergen house dust mite.@*METHOD@#Four hundred and twenty-five patients with suspected allergic rhinitis and asthma in our area accepted skin prick tests of 10 standard allergen agents and specificity IgE detection. The different positivity ratios of allergens in different age groups were compared and the correlation between the two different technique methods testing the dust mite allergen was analyzed.@*RESULT@#Among 425 patients with suspected allergic rhinitis and asthma in our area, 298 patients were positive and 89 patients suffered a combined allergic asthma. House dust mite (292 cases) and dermatophagoides farinae (289 cases) were the commonest allergens. The other common allergens were mugwort (45), ragweed (31), fungus I (19), fungus II (15), spring-pollen II (14), poly-animal hair (14), spring-pollen I (9), poly-feather (3). There was a correlation between skin test and sIgE test for house dust mite, dermatophagoides farinae in children group, and the positivity ratios were significantly higher than the adults group.@*CONCLUSION@#Dust mite is the most important allergen in allergic rhinitis and asthma in Jingmen.
Subject(s)
Adolescent , Adult , Animals , Child , Female , Humans , Male , Middle Aged , Young Adult , Allergens , Allergy and Immunology , Asthma , Diagnosis , Epidemiology , Allergy and Immunology , China , Epidemiology , Immunoglobulin E , Blood , Pyroglyphidae , Rhinitis, Allergic, Perennial , Diagnosis , Epidemiology , Allergy and Immunology , Skin TestsABSTRACT
OBJECTIVE@#To investigate the profiles of inhaled allergens in allergic rhinitis patients in district of Jingmen, and to provide basic epidemiologic information for the prevention and treatment of allergic rhinitis in this area.@*METHOD@#Retrospectively analyze 10 allergens skin prick test results of 1800 allergic rhinitis patients recruited.@*RESULT@#The most common inhaled allergens in allergic rhinitis patients in our area were house dust mite (76.83%), dermatophagoides farinae (75.50%), mugwort (10.50%), ragweed (7. 39%), fungus II (6.28%), fungus I (5.83%), spring-pollen I (4.44%), spring pollen II (3.72%), poly-animal hair (3.56%), poly-feather (1.89%). Moreover, the positivity frequencies of house dust mite and dermatophagoides farinae were decreased with age increasing.@*CONCLUSION@#House dust mite and dermatophagoides farinae were the most common allergens in allergic rhinitis patients in Jingmen area.