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Objective To compare the efficacy and safety of transurethral plasmakinetic resection of the prostate(TUPKRP)and transurethral resection of prostate(TURP). Methods A total of 36 elderly patients with large volume prostate and high-risk benign prostatic hypertrophy were involved in this study.Among them,16 patients underwent PKRP and 20 patients underwent TURP.The operation time,blood loss,resected prostate weight,continuous bladder irrigation time,catheterization time,international prostate symptom score(IPSS)and Omax 6 months post-operation were compared between PKRP group and TURP group. Results There was no significant difference in all parameters except the blood losss between the 2 groups.The blood loss was less in TUPKRP group than in TURP group[(283±155)ml vs.(465±264)ml,P<0.05],and no blood transfusion needed during operation in TUPKRP group(O case vs.2 cases,P<0.01).However,IPSS and Omax 6 months post-operation improved significantly as compared with preoperation in the 2 groups(PKRP:(27.8±3.5)vs.(6.8±3.4),(4.5±2.7)ml/s us.(15.8±6.2)ml/s;TURP:(29.2±6.1)vs.(7.4±4.2),(5.2±3.6)ml/s vs.(15.2±5.3)ml/s,all P<0.01). Conclusions The effect of TUPKR is similar to TURP,but TUPKR is more safety than TURP for the elderly patients with large volume and high-risk BPH.
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Objective To discuss the diagnosis and treatment experience of primary ureteral cancer.Methods We retrospectively analyzed the clinical data of 24 patients with ureteral carcinoma treated in Beijing hospitals between 2001～2007.Compared various examination methods and tried to figure out the existing problems in the diagnosis and treatment.Results The preoperative diagnosis of 22 in 24 cases were clarified,19 of them received surgery.Postoperative pathology reports show of the 19 cases18 have pathology classification as transitional cell carcinoma,only 1 concurrent with small squamous cell carcinoma.Conclusion The combination of different examination method include B-type ultrasonic inspection,IVP,cystoscopy,retrograde pyelography,the detection of cancer cells from urine,CT,MRI and ureteroscopy can increase the preoperative diagnosis rate of primary ureteral carcinoma.The B-type ultrasonic inspection is a basic screening tool,cystoscopy + retrograde pyelography check is the most important examination.Surgery is the major treatment.Sleeve resection of the affected kidney-ureter-bladder is the primary choice of treatment of ureteral cancer.The prognosis mainly depends on the tumor stage and grade,so improve early diagnosis of great significance.
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Objective To improve the management of the complications in patients with advanced prostate cancer. Methods Bone pain, anemia, urinary tract obstruction, hematuria and edema in the lower extremities and scrotum of patients with prostate cancer were managed with analgesics(24 cases), bisphosphonates(14 cases), isotope strontium-89(6 cases), external beam irradiation(9 cases), blood transfusion(9 cases), TURP(7 cases), superpubic cystostomy(8 case), percutaneous nephrostomy(4 case) and cysto-irrigation(6 case). Results 16 patients were alived and 10 were died of respiratory or circulation failure . The patients were relieved from pain and the other complications for several months after the palliative measures had been taken. Conclusions Bone pain, anemia, urinary tract obstruction and hematuria are common complications of advanced prostate cancer. They may have great impact on the life quality of patients. Diverse therapeutic modalities should be employed to palliate these disabling symptoms.
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To investigate the relationship between the effects of arecoline hydrobromide on contraction of the smooth muscles in oncomelania foot, and explore the mechanism of arecoline hydrobromide in decreasing climbing adhesion and increasing snail－killing. Method: The in vitro experiment was used to observe the effects of arecoline hydrobromide on contraction activitive of foot smooth muscles of oncomelania. Results: With a concentration of 3×10-6mol*L-1, arecoline hydrobromide strengthened the contraction and increased the frequency of the contraction of the foot smooth muscles of oncomelania, which was antagonized by verapamil. The same concentration of arecoline hydrobromide enhanced the contraction of smooth muscles in Ringer's solution with ECTA but Ca2+, and this effect was antagonized by caffeine. The concentrations of 10－5 and 3×10－5mol*L-1 of arecolin hydrobromide blocked the effect of Bay K8644 in enhancing foot smooth muscle contraction, with a characteristic of concentration－dependence. Conclusion:Arecoline hydrobromide may block the calcium channel of the smooth muscles in oncomelania foot. This could provide an explanation why arecoline hydrobromide decreases the rate of oncomelania climbing adhesion and enhances snail－killing.