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Objective To analyze the research focuses and frontiers of exercise intervention on breast cancer patients. Methods We collected 7134 pieces of literature about exercise intervention on breast cancer in the Web of Science Core Collection database in recent five years, and CiteSpaceⅤ was used to conduct visual knowledge map analysis and generate a visual map including discipline distribution, country or region distribution, keyword co-occurrence or highlighting, keyword timeline maps, etc. Results In recent years, the domain of exercise intervention on breast cancer has achieved rapid development. The disciplines were mainly cardiovascular system and cardiology as well as oncology. Countries such as the United States, the United Kingdom and Italy ranked in the first places with regard to the number of papers. The body mass index and the quality of life betweeness centrality were respectively 0.81 and 0.52, which played an important role in the knowledge map. The keyword highlighting map and the timeline map showed that cardiac toxicity was a research focus in this domain. Conclusion The research focuses of exercise intervention on breast cancer are mainly cardiovascular and related fields, in a rapid development stage. Future research directions include weight control, quality of life and cardiac toxicity.
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<p><b>BACKGROUND</b>The prevalence of metabolic syndrome (MetS) increased recently and there was still not a screening index to predict MetS. The aim of this study was to estimate whether brachial-ankle pulse wave velocity (baPWV), a novel marker for systemic arterial stiffness, could predict MetS in Chinese community population.</p><p><b>METHODS</b>A total of 2 191 participants were recruited and underwent medical examination including 1 455 men and 756 women from June 2011 to January 2012. MetS was diagnosed according to the criteria of the International Diabetes Federation (IDF). Multiple Logistic regressions were conducted to explore the risk factors of MetS. Receiver operating characteristic (ROC) curve was performed to estimate the ideal diagnostic cutoff point of baPWV to predict MetS.</p><p><b>RESULTS</b>The mean age was (45.35±8.27) years old. In multiple Logistic regression analysis, the gender, baPWV and smoking status were risk factors to MetS after adjusting age, gender, baPWV, walk time and sleeping time. The prevalence of MetS was 17.48% in 30-year age population in Shanghai. There were significant differences (χ(2) = 96.46, P < 0.05) between male and female participants on MetS prevalence. According to the ROC analyses, the ideal cutoff point of baPWV was 1 358.50 cm/s (AUC = 60.20%) to predict MetS among male group and 1 350.00 cm/s (AUC = 70.90%) among female group.</p><p><b>CONCLUSION</b>BaPWV may be considered as a screening marker to predict MetS in community Chinese population and the diagnostic value of 1 350.00 cm/s was more significant for the female group.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Ankle Brachial Index , Methods , Logistic Models , Metabolic Syndrome , Diagnosis , ROC CurveABSTRACT
The antitumor effect and the mechanism of action of ursolic acid in A549 cells(human non-small-cell lung cancer cells) was investigated in this paper. Firstly, MTT assay was performed to test whether ursolic acid could inhibit the growth of A549 cells. Secondly, Western blot was utilized to measure the expression level of COX-2 and the activation of MAPKs. The MTI assay revealed that ursolic acid inhibited the growth of A549 cells. The result of Western blot suggested that ursolic acid inhibited the expression of COX-2 and activation of ERK and ERK specific inhibitor PD98059 suppressed the expression of COX-2 synergistically with ursolic acid. Taken together, our data suggest that ursolic acid can suppress LPS-induced COX-2 expression in A549 cells, which could be due to the inhibition of the activation of ERK.