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[ ABSTRACT] AIM:To investigate the effect of Jia-jian-yi-yin decoction on endothelium-dysfunction in ovariecto-mized rats.METHODS:The ovariectomized rats were treated with Jia-jian-yi-yin decoction or turbid liquid of estradiol va-lerate for 8 weeks.The vascular ring tension was measured.Scanning electron microscopy and Western blotting were ap-plied to assess the function of endothelium-dependent dilation, aortic endothelial morphology and the expression of endothe-lial lipase.The pathologic sections were prepared to observe the effect of Jia-jian-yi-yin decoction on the uterus.RE-SULTS:In ovariectomized rats, the decrease in endothelium-dependent relaxation to acetylcholine ( ACh) was reversed to normal level, the endothelial morphology returned to normal without lipid accumulation and the endothelial lipase expression was decreased by Jia-jian-yi-yin decoction.Furthermore, no obvious change of the wet weight of uterine between the ovari-ectomized rats with or without Jia-jian-yi-yin decoction treatment was observed.CONCLUSION:Jia-jian-yi-yin decoction may have protective effects on endothelium-dependent vasodilation and aortic endothelial morphology in estrogen-deficient animals.
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ObjectiveTo evaluate the efficacy of preoperative transarterial chemo-embolization and radical surgery for renal carcinoma.MethodsA lotal of 68 cases underwent transarterial chem-embolization by injecting lipiodcl-MMC emulsion,DDP,ADM and gelain sponge successfully and 64 of them underwent radical surgery 82～110 h after embolization.The efficacy was retrospectively studied.ResultsPreoperative transarterial chem-embolization made resection easier,with 1,3,5,and 8 year survival rate being 91.7%,83.3%,66.7% and 45.0%,respectively.The side effect of chemo-embolization were lumbago in all,fever in 52,gastrointestive reaction in 48.No extra-renal embolization has been noted.ConclusionsPreoperative transarterial chem-embolization is helpful and is highly recommented as a preoperative routine procedure.It might serve as one of the main procedures for non-operatabe cases.