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Objective To explore the clinical feature of severe enterovirus 71 (EV71) associated hand foot and mouth disease (HFMD),and genotype of EV71.Methods Fluorescent quantitation PCR was done for detecting EV71.RT-PCR was performed to amplify VP1 for sequencing and identifying genotype.A retrospective analysis was performed based on the clinical data of 15 cases with severe EV71 infection.Results EV71 nucleotide was positive in all 15 cases.The genotype of EV71 was C4.All cases had abnormal temperature and followed with nervous symptoms in the early stage.Average time was 1.26 days from onset to severe complications appearance.Eleven cases progressed to neurogenic pulmonary edema.Four cases accepted nasal continuous positive airway pressure.Eleven cases accepted oral trachea cannula mechanical ventilation.Except for 3 cases died,one case abandoned,others 11 cases were cured.Conclusion The isolated strains of EV71 in this study are all C4 genotype.All cases with severe EV71 infection were followed with nervous symptoms in the early stage,most of whom would progress to neurogenic pulmonary edema.The mortality would be cut down by using mechanical ventilation in early stage.
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@# 目的观察护理干预措施对癌症化疗患者呕吐症状的改善情况。方法100例化疗呕吐患者分为试验组和对照组,每组50例。两组均采取临床化疗方案、对症治疗、常规护理,试验组同时给予护理干预。结果在化疗结束时,两组患者的呕吐症状均有减轻,但试验组患者症状改善优于对照组(P<0.05)。结论护理干预能有效减轻癌症化疗患者的呕吐症状。
ABSTRACT
@# 目的观察护理干预措施对癌症化疗患者呕吐症状的改善情况。方法100例化疗呕吐患者分为试验组和对照组,每组50例。两组均采取临床化疗方案、对症治疗、常规护理,试验组同时给予护理干预。结果在化疗结束时,两组患者的呕吐症状均有减轻,但试验组患者症状改善优于对照组(P<0.05)。结论护理干预能有效减轻癌症化疗患者的呕吐症状。
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk factors for congenital external malformation.</p><p><b>METHODS</b>A 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000.</p><p><b>RESULTS</b>Simple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612).</p><p><b>CONCLUSIONS</b>Congenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.</p>