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Objective:To understand the cognitive and positive coping strategies of postoperative chemotherapy patients with nausea and vomiting, and to provide a basis for clinical nurses to develop targeted intervention programs.Methods:From May to July 2019, 15 patients with postoperative adjuvant chemotherapy breast cancer who were hospitalized for breast surgery were selected by the purpose sampling method. The phenomenological research method in qualitative research was used to interview them. The Colaizzi data analysis principle was used to analyze the data and refine the theme.Results:Four themes were extracted through analysis: the perception of nausea and vomiting; the accompanying symptoms of nausea and vomiting; nausea and vomiting have different effects on patients' emotions and social interactions; patients adopt various ways to actively deal with nausea and vomiting, including self-regulation, behavioral adjustment, social support, and seeking professional help.Conclusions:Medical staff should pay attention to the nausea and vomiting of patients undergoing postoperative chemotherapy for breast cancer and the coping strategies adopted, and timely evaluate and intervene to alleviate the symptoms and improve their quality of life.
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Objective@#To evaluate the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI MRI) in the evaluation of tumor vascular normalization in a mouse model of colorectal cancer induced by recombinant human endostatin (rhES).@*Methods@#The CT26 colorectal cancer xenograft model of BALB/c mice were established and divided into rhES group and control group, with 20 mice in each group. The mice of rhES group were intravenously injected with rhES 5 mg·kg-1·d-1 once daily for 12 days, while the mice of the control group were intravenously injected with the same volume of 0.9% saline. 5 mice of rhES group and control group were randomly selected to perform IVIM-DWI MRI as following times: before treatment and four, eight, twelve days after treatment. The parameters of IVIM-DWI were recorded, including true diffusion coefficient(D), pseudo-diffusion coefficient (D*) and perfusion fraction (f). Meanwhile, microvessel density (MVD), pericyte coverage and tumor perfusion in tumor tissues were detected by immunofluorescence, respectively.@*Results@#The tumor volumes of control group and rhES group before treatment were (154.42±24.65) mm3 and (174.24±28.27)mm3, respectively, without statistically significant difference (P=0.440). From day 2 to day 12 after treatment, the tumor volume of rhES group was significantly smaller than that of control group (all P<0.05). There were no statistical significances of D value between the rhES group and control group before and after treatment (all P>0.05). The D* values of the rhES group were (10.940±2.834)×10-3mm2/s and (12.940±2.801)×10-3mm2/s in day 4 and 8 after treatment respectively, significantly higher than (6.980±1.554)×10-3mm2/s and (7.898±1.603)×10-3mm2/s of control group (P<0.05). Moreover, compared with control group, the D* value of rhES group was significantly lower in day 12 (6.848±1.460)×10-3mm2/s vs (9.950±2.596)×10-3mm2/s, (P<0.05). The f value of rhES group in day 8 was (0.226±0.021)%, significantly higher than (0.178±0.016)% of control group (P<0.01). The MVD of rhES group was significantly lower than that of control group (P<0.05), while the pericyte coverage and tumor perfusion of rhES group were significantly higher than those of control group in day 4 and 8 after treatment (all P<0.05). In addition, we found D* value of IVIM-DWI in rhES group was significantly related with MVD, pericyte coverage and tumor perfusion (r=-0.354, r=0.555, r=0.559, all P<0.05). Meanwhile, the f value in rhES group was also significantly related with MVD, pericyte coverage and tumor perfusion (r=-0.391, r=0.538, r=0.315, all P<0.05).@*Conclusions@#IVIM-DWI MRI can effectively evaluate the vascular normalization in rhES-induced CT26 colorectal tumor.The parameters D* and f are closely related to intratumorally microvessel density, pericyte coverage and perfusion, which can effectively monitor the occurrence of tumor vascular normalization time.
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Objective To investigate dilatancy effect of the Hypertonic Sodium Chloride Hydroxythyl Starch 40 injection (HSH) for the treatment of hemorrhagic shock.Methods 70 cases with trauma induced hemorrhagic shock were randomly divided into two groups:Hypertonic Sodium Chloride Hydroxythyl Starch 40 injection group (H group), Ringer's group (R group), 35 cases in each group.Patients of H group were infused HSH10ml/kg within 30 minutes, the R group were infused Ringer's 10ml/kg at the same time.Central venous pressure (CVP), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SpO2) were monitored before the infusion, after the infusion and finished 30 minutes separately.Na+、Cl-、K+ were examined before infusion and after infusion respectively.Results The CVP、SBP、DBP、HR and SpO2 in both groups were improved than before infusion, but those in H group is much better than R group, with statistical significance (p<0.05).The potassium was reduced moderately and sodium ions and chloride ions were increased in H group than in R group, but it was still within normal range.Conclusion Appling HSH (10ml/kg) to patients with hemorrhagic shock can be better than the compound prescription of sodium lactate.
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Objective To investigate the effect of prophylaxis against respiratory and circulation depression caused by propofol during painless colonoscopy by intravenous doxpram with small dose.Methods 80 patients undergoing painless colonoscopy were randomly divided into the control group(A group) and the doxpram group(B group).All patients used propofol,and then used propofol after induction.In group B,doxpram was injected before anesthesia.The degree and incidence rate of respiratory and circulotion depression,the dose of propofol,the awake time,the examination time,the complication during anesthesia and awake were monitored.Results The SBP,DBP,SpO2,RR during anesthesia were obviously lower in group A than in group B(P
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0.05).ANH average artery pressed to descendobviously after hemodilution(P
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Objective To investigate the effect and clinical valve of target-controlled infusion of remifentanil for conscious intubation of patients under fibrobronchoscopy.Methods Forty patients were randomly divided into two groups(F and R),each group contained 20 cases.All of the patients were intubated on regional anaesthesia,as the first step,then the patients in F group were given fentanyl 2?g/kg by vein.In remifentanil target-controlled infusion group(R group),the patients were kept infusing remifentanil 2ng/ml.Results (1)Haemodynamics:in R group,SBP and HR kept steadily;In F group,while the two indices increased significantly.(2)Static pulmonary function:in R group,RR,VT deceased remarkablely.There were no difference between two groups in SpO_2 and P_ ET CO_2.(3)Tracheal intubating condition and Ramsay score in R group were better than in F group;Cardiovascular response in R group was lower.Conclusion Target-controlled infusion of remifentanil for conscious intubation can achieve excellent result,with less cardiovascular response.