ABSTRACT
<p><b>OBJECTIVE</b>To optimize the combination modes of medical materials in extract of Huanglian Jiedu decoction.</p><p><b>METHOD</b>Divided the medical materials of Huanglian Jiedu decotion into 15 groups and extracted by semi-bionic estraction (SBE), the contents of berberine, baicalin, geniposide, total alkaloid, total flavonoid, total integral calculus area of HPLC and extract of 1 000 were determined, standardized, weighted and evaluated, respectively.</p><p><b>RESULT</b>The maximum evaluated value Y for the extracting technique was AD + BC.</p><p><b>CONCLUSION</b>The optimal combination mode of the perscription is that Rhizoma Coptidis and Fructus Gardeniae, Radix Scutellariae and Cortex Phellodendri Amurensis are decocted together respectively then the two decoctions are merged.</p>