ABSTRACT
Objective To investigate the clinical application effects of tracheal intubation under general anesthesia guiding by HC visual laryngoscope in combination with fiberoptic bronchoscopy via clinical studies.Methods A total of 348 patients underwent the tracheal intubation under general anesthesia in the hospital between January 2013 and January 2015 were randomly selected and Divided into three groups according to different ways of guiding tracheal intubation.The first group was a simple fiber light guide bronchoscopy to guide the general anesthesia tracheal intubation was set to F group,In the second group,the general anesthesia tracheal intubation was set to H group for the simple HC video.The third group was HC video mirror combined with fiber light guide bronchoscopy to guide the general anesthesia tracheal intubation was set to H+F group.The general condition and intubation conditions such as the time and frequencies of intubation in three groups were recorded respectively.Results The general condition,age,BMI index,thyromental distance,interincisor distance value were similar among three groups.The time needed for intubation was the longest in group F up to (41 ± 11) s.The highest frequency of intubation was in group H with 30 times,and the time of glottis exposure was the longest in group F as (21 ± 9) s.The difference among groups and intra-groups has statistical significance (P＜0.05).Conclusion HC visual laryngoscope in combination with fiberoptic bronchoscopy guiding tracheal intubation under general anesthesia has a good effect in clinical practice,and is worthy of clinical promotion.
ABSTRACT
Objective To investigate cytochrome P450 1A2~* 1C gene polymorphism in Dai and Han nationality volunteers from Dehong autonomous prefecture in Yunnan province. Methods One hundred and seventeen Dai and 112 Han nationality volunteers from Dehong autonomous prefecture in Yunnan province were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in genotyping analysis. Results There were 45 wild-type homozygotes (G/G), 63 heterozygotes (G/A) and 9 homozygotes among 117 Dai nationality volunteers, while 63 wild-type homozygotes (G/G), 44 heterozygotes (G/A) and 5 homozygots among 112 Han nationality volunteers. There was significant difference in the incidences of the genotypes between the two populations (P<0.05). The distribution of the genotypes of either population was in Hardy-Weinberg equilibrium. The frequency of the allele A in the 1ocus-2964 of CYP1 A2 was 35% (95% CI30%-40%) and 24% (95% CI 20%-30%) respectively in Dai and Han nationality volunteers. There was significant difference in the frequency between two populations (P<0.05). There was also significant difference in the frequency between Dai nationality volunteers and the populations of other regions. Conclusion CYP1A2~*1C gene polymorphism is one of factors of producing individual and racial variation in pharmacology in Dai and Han people from Dehong autonomous prefecture in Yunnan province.