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OBJECTIVE To explore the rational application of aminoglycosides antibiotics.METHODS We randomly selected 520 patients' records of applying aminoglycosides antibiotics from Jan to Dec in 2007.Types of antibiotics,dosages,usage,ways of delivery and periods and combination of medicines were analyzed.RESULTS Out of the 520 cases,the oldest patient was 89 year and the youngest one was 7 years.The application rate of amikacin was the highest(35.6%),which was delivered mainly by iv,the combination of medicines accounted for 92.7%.CONCLUSIONS The application of aminoglycosides antibiotics in our hospital is basically rational.In some cases the improper antibiotics are used and the duration is a little longer,which should be supervised.
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OBJECTIVE:To prepare Xielong liquor and establish its quality control.METHODS:Xielong liquor was prepared by classic merceration.Paeonia lactiflora in the formulation was identified by TLC,and the content of the active component ferulaic acid was determined by HPLC.RESULTS:The preparation was yellowish-brown in color and its TLC spots were clear and well-isolated.The linear range of ferulaic acid was 3.66～36.64 mg?L-1(r=0.999 8)and its the average recovery was 100.47%(RSD=0.84%,n=15).CONCLUSION:The preparation technology of Xielong liquor is simple and feasible and the quality of the preparation is stable and controllable,thus the established standard is applicable for the quality control of Xielong Liquor.
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Objective To investigate the correlations between chlamydia pneumoniae (Cpn) infection and acute myocardial infarction (AMI). Methods Specific Cpn antibodies and the DNA were measured in 51 patients with AMI (AMI group), 42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery diseases. Moreover, the changes of and relationships between fibrinogen (Fg), hemorheological parameters and Cpn infection were determined in the three groups. Results The positive rates and levels of Cpn IgG and Cpn IgM in the AMI group were higher than those in the NC group (P
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Objective: To observe the effects of exposure to white noise on the procession of learning and memory, and the expression of NOS (nitric oxide synthase) in hippocampus of rats Method: 20 rats were randomly divided into two groups for observation of spatial learning and memory, one group exposed to 80 dB white noise during Y-maze training, the other group received Y-maze training under normal condition Another 24 rats were randomly divided into 3 groups, they experienced normal Y-maze training, noise Y-maze training and sole noise as control respectively Immunohistochemical assay was used to investigate the expression of NOS positive neurons Result: Noise hampered the ability of rats' spatial learning and memory, furthermore, the number of NOS positive neurons in hippocampus of noise training group was less than that of normal training group Conclusion: The activity of NOS positive neuron in hippocampus was decreased by exposure to noise, suggesting the inhibition of learning dependent long term procession in hippocampus and corresponding difficulty in obtaining and maintaining of memory
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OBJECTIVE: To establish the preparation process and method of quality control of dilute atropine sulfate eye-drops.METHODS: Mixing atropine sulfate with additives in water to prepare 0.04% atropine sulfate eye-drops.And determined the content of atropine sulfate by HPLC,the system consisted of C18 column and mobile phase of acetonitrile-water (55∶45).RESULTS: The product is colorless and clearing liquid.The linear range of atropine sulfate was 10～60?g/ml(r=0.9 999).The average recovery rate was100.2%(RSD=0.95%,n=9).CONCLUSION: The preparation process of dilute atropine sulfate eye-drops is simple and the method of quality control by HPLC is reliable.