Effect of bilirubin derivative on HIV-1 in vitro / 中华实验和临床病毒学杂志

<p><b>BACKGROUND</b>To study the effect of DTB against HIV-1, for developing anti-HIV drugs.</p><p><b>METHODS</b>Different concentration of DTB was added to cell culture system after viral inoculation, MTT staining method for viable cells (MTT assay) and p24 (ELISA) were used as markers to monitor the viral replication.</p><p><b>RESULTS</b>The inhibition rates of DTB at concentrations 160, 80, and 40mg/ml were 93.0%, 56.2% and 18.1%, respectively.</p><p><b>CONCLUSIONS</b>DTB could effectively inhibit HIV-1 in vitro.</p>