ABSTRACT
Objective@#To explore the clinical characteristics and prognosis of pulmonary tuberculosis in children with human immunodeficiency virus (HIV)/ acquired immunedeficiency syndrome (AIDS).@*Methods@#A retrospective analysis was made on the clinical data of 23 children with HIV/AIDS and tuberculosis who were cultured positive for Mycobacterium tuberculosis, including general data, laboratory examinations, imaging data and disease outcomes.@*Results@#The percentage of CD4+ T lymphocytes<50/mm3 was 43.48% (10≤23) in 23 children. The proportion of appetite loss, fever, cough and fatigue was 86.95%, 82.61%, 82.61% and 78.26% respectively. Atypical symptoms such as rash, joint muscle stiffness and vomiting could be seen. The proportion of multi-site and patchy shadow on chest radiography was 47.83% and 43.48% respectively. There were 1 case of oral mucosal leukoplakia, 1 case of herpes zoster and 1 case of Pneumocystis carinii pneumonia. Nineteen children were followed up regularly after they were discharged from hospital. In 2 cases the treatments were ineffective or the diseases worsened, and two cases died.@*Conclusions@#The clinical manifestations of children with HIV/AIDS complicated with tuberculosis were lack of specificity. The general manifestations and extrapulmonary manifestations were serious. Chest imaging manifestations are mostly multi-site and patchy shadows. Early diagnosis and treatment of HIV/AIDS in children are very important.
ABSTRACT
Objective:To develop lipiodol-containing calcium alginate microspheres (LAMs) for embolization,and study the characterization for emoblization and the radiopacity. Methods:LAMs were prepared by dripping method. The preparation of LAMs was optimized by orthogonal experiment which involved effects of three factors (the volume ratio of lipiodol to the external aqueous solution,airflow rate,and the weight pushing the injector) at three levels on the responses to the size,polydisperse index and entrapment efficiency of LAMs. The morphology of LAMs was observed under microscope. The elasticity of LAMs was investigated by texture analyzer. The capability injected through catheter of LAMs was monitored by video spinning-drop tensionmeter. The radiopacity of LAMs was measured by X-ray imaging system after LAMs were injected into vas of a rat. Results:The optimal condition for preparation of LAMs was:the volume ratio of lipiodol to the external aqueous solution was 3∶ 10,airflow rate was 40 g/mL and the weight pushing the injector was 100 g. According to the optimized condition,LAMs were prepared and characterized. The mean diameter of LAMs was (493.9?42.6) ?m,the polydisperse index was 1.02 and the entrapment efficiency was (88.97?1.09)%. The LAMs were with round shape and smooth surface in view of photograph of microscope. The maximum average load was (1.09?0.18) N when LAMs were compressed to 60%. The LAMs were injected through catheter without much difficulty. The radiopacity of LAMs in rats was demonstrated to be visible under X-ray photography system. Conclusion:The radiopaque LAMs developed are suitable for the arterial embolization,with round shape,proper size,good elasticity,easy handling character and visible property under X-ray imaging. The radiopaque embolic agent is supposed to be useful for emoblization therapy.