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Objective To systematically review the effect of proprioceptive training for knee joints recovery among patients with total knee replacement (TKR).Methods We searched Chinese BioMedical Literature Database,CNKI,WanFang database,Chinese Scientific Journals Full-text Database,PubMed,EMbase,MEDLINE and Cochrane Library for randomized controlled trials (RCT) about proprioceptive training for knee joint recovery after TKR and the retrieval covered the period to November 2017.Two reviewers independently selected studies,extracted data,evaluated quality,and analyzed data,which was conducted using the RevMan software.Results Five studies involving 278 patients were selected.Meta-analysis showed that the knee joint function score was significantly increased in the proprioceptive training group than that in the control group [standard mean difference (SMD) =0.38,95％ CI (0.26,049),P＜0.0001].Moreover,proprioceptive training could significantly improve the joints' function (P=0.0006),up-regulate the joints' range of motion (P=0.006) and increase the strength (P=0.005) and stability (P＜0.0001) of knee joints compared with those in the control group.Conclusions Proprioceptive training on the basis of routine rehabilitation can improve the joints' stability,enhance the balance and coordination,and increase the quality of life in elderly patients after TKR,and could be recommended as a comprehensive rehabilitation program.
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Objective To systematically review the efficacy of anodal transcranial direct current stimulation (A-tDCS) for relieving aphasia among stroke survivors.Methods The Chinese BioMedical Literature database,China National Knowledge Infrastructure,WanFang database,Chinese Scientific Journals full-text database,PubMed,Embase,MEDLINE and the Cochrane Library for clinical randomized and controlled trials were searched for reports about the use of A-tDCS in the treatment of aphasia after stroke.The resulting reports were retrieved manually and evaluated by two independent reviewers according to pre-set inclusion and exclusion criteria.The reports covered the period to November 2016.A meta-analysis was then conducted using RevMan software version 5.3.Results Seven studies covering 101 patients were selected for analysis.Meta-analysis showed that the average aphasia function score improved after A-tDCS significantly more than in the control group.Picture naming ability in stroke survivors with aphasia showed particular improvement.Only 11 patients in the 7 studies presented light adverse effects from AtDCS,always within the patients' tolerance range.Conclusion A-tDCS can significantly improve the speech of patients with aphasia after cerebral infarction.It is safe and easy to administer and is a rehabilitation technology worth popularizing and applying.Considering the limited number of articles,the conclusion remains to be further verified with randomized clinical trials of higher quality and a larger sample.
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Objective To construct a lentiviral vector carrying rat sirt1 gene and observe the expression of sirt1 in retinal ganglion cell (RGC) of rat.Methods Rat sirt1 cDNA was inserted into pLV5 vector.After identification by sequencing analysis and PCR,the recombinant sirt1expressinglentivirus vector was packaged by cotransfecting 293T cells with packaged plasmid.Then pLV5-sirt1 was used to infect the cultured Sprague-Dawley rat RGC cell in vitro.The expressions of sirt1 protein and mRNA in infected rat RGC were detected by quantitative real-time PCR and Western blot.Results The sirt1 expression vector pLV5 was successful constructed and sequence was proved to be correct.The expression of sirt1 protein and mRNA in RGC was significantly increased than that in cells infected with control lentiviruses (P ＜ 0.05).Conclusion We have successful constructed a sirt1 expression lentivirus vector pLV5-sirt1 and it can increase the expression of sirt1 protein and mRNA in the rat retinal ganglion cells.
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Objective To investigate the clinical efficacy of body weight supported treadmill training (BWSTT) for the recovery of walking ability and comprehensive function after thoracolumbar spinal cord injury (SCI).Methods Sixty patients with SCIs in a thoracolumbar segment were assigned to a treatment group or a control group with 30 in each.Both groups received similar conventional rehabilitation training,but the patients in the treatment group were additionally treated with BWSTT (30 to 40 min,once daily,5 d/week,30 days for a course,a total 3 courses).The American Spinal Injury Association lower-extremity motor function assessment (ASIA),a functional comprehensive assessment (FCA),the walking ability assessment from the FCA (WA) and the modified Barthel index (MB1) were used in the assessment of the two groups before and after treatment.Results There were no significant differences in the two groups＇ average ASIA,FCA,WA or MBI results before treatment.After treatment ASIA,FCA,WA and MBI scores had all increased significantly in the treatment group compared with before treatment,and were significantly higher than in the control group.Conclusion As a supplement to conventional rehabilitation,BWSTT can improve walking ability and comprehensive function significantly after thoracolumbar spinal cord injury.
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Objective To investigate the value of external counterpulsation and cervical traction therapy on patients with vertebral artery insufficiency syndrome. Methods Based on the criteria of clinical diagnosis, 90 patients with vertebral artery insufficiency syndrome were randomized into three groups. The group A was treated with external counterpulsation (30 cases), the group B with cervical traction (30 cases)and the group C with cervical traction plus external counterpulsation (30 cases). Results There was better therapeutic effects in group C as compared with groups A and B (P0.05). Conclusion External counterpulsation and traction therapy are effective in the treatment of the vertebral artery insufficiency syndrome.