ABSTRACT
In accordance with this Journal's policy, the entire article has been retracted at the request of the Editors.
ABSTRACT
In accordance with this Journal's policy, the entire article has been retracted at the request of the Editors.
ABSTRACT
Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SMHL) is a benign histiocytic proliferative disorder of unknown etiology. The disease is usually accompanied by massive bilateral lymphadenopathy, fever, elevated erythrocyte sedimentation rate, leukocytosis with neutrophilia, and polyclonal hypergammaglobulinemia. Histopathologic examinations showed characteristically large histiocytes exhibiting emperipolesis. On immunohistochemical stains, histiocytes are positive for CD68 and S-100 protein, but negative for CD1a. The lymph node involvement is typical, but it may also involve other systemic organs in one third of the cases such as skin, upper respiratory tract, bones and so on. Patients with purely cutaneous Rosai-Dorfman diseases are of older age at onset of the disease with a reversed male/female ratio, thus, cutaneous Rosai-Dorfman disease is recognized as a distinct entity from the Rosai-Dorfman disease. Herein, we present a 50-year-old man with erythematous papules and indurated plaques on both cheeks, diagnosed as cutaneous Rosai-Dorfman disease. The lesions were treated with isotretinoin 10 mg bid for 9 months with pulsed dye laser.
Subject(s)
Humans , Blood Sedimentation , Cheek , Coloring Agents , Emperipolesis , Fever , Histiocytes , Histiocytosis, Sinus , Hypergammaglobulinemia , Isotretinoin , Lasers, Dye , Leukocytosis , Lymph Nodes , Lymphatic Diseases , Respiratory System , S100 Proteins , SkinABSTRACT
Cervical cancer is the seventh most common malignancy in women. But, not many cases of cutaneous metastasis have been reported. We report a cases of a 45-year-old woman presenting with multiple erythematous nodules on the right flank. She had small cell cervical cancer with multi-organ metastasis, including the pancreas, lymph nodes, and lung. A skin biopsy revealed small cell cancer features throughout the dermis, and immunohistochemical tests were positive for chromogranin and synaptophysin. Based on these clinical and histopathological findings, we concluded that her condition was skin metastasis at the right flank from cervical cancer, which occurs very rarely.